153754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2477793..2478385 Replicon chromosome
Accession NZ_CP051194
Organism Treponema sp. OMZ 855

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4N65_RS11250 Protein ID WP_253673307.1
Coordinates 2477793..2478047 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4N65_RS11255 Protein ID WP_044014553.1
Coordinates 2478044..2478385 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N65_RS11220 (E4N65_11240) 2473115..2473672 - 558 WP_044014561.1 STAS domain-containing protein -
E4N65_RS11225 (E4N65_11245) 2473752..2474468 - 717 WP_044014559.1 SDR family oxidoreductase -
E4N65_RS11230 (E4N65_11250) 2474575..2475345 + 771 WP_253673303.1 RNA methyltransferase -
E4N65_RS11235 (E4N65_11255) 2475302..2476441 - 1140 WP_253673304.1 sigma 54-interacting transcriptional regulator -
E4N65_RS11245 (E4N65_11265) 2476880..2477731 + 852 WP_253673305.1 Fic family protein -
E4N65_RS11250 (E4N65_11270) 2477793..2478047 + 255 WP_253673307.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N65_RS11255 (E4N65_11275) 2478044..2478385 + 342 WP_044014553.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N65_RS11260 (E4N65_11280) 2478409..2479392 - 984 WP_253673309.1 M28 family peptidase -
E4N65_RS11265 (E4N65_11285) 2479411..2481243 - 1833 WP_253673311.1 oligoendopeptidase F -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9614.11 Da        Isoelectric Point: 10.4281

>T153754 WP_253673307.1 NZ_CP051194:2477793-2478047 [Treponema sp. OMZ 855]
MNSKQKKVYEAIFKNPVQSDIEWQEIENLLHSLGAKISEGNGSRIRIELKGERAVFHRPHPEKVTDKGAIKSMRKFLENA
GIKI

Download         Length: 255 bp

>T153754 NZ_CP067071:2423924-2424334 [Rhizobium sp. AB2/73]
ATGTATCTCGTCGATACCAACGTCGTCTCGGAACTCCGGCGCGGCAATTCCCAAGCGATTGCGTGGCTGCGCTCGGTCGA
TCCCTCCACCATTTATCTGAGTGTCATCACACTCGGAGAGATCATGCGTGGGATTGCGCTCAAGCGAAAATCGGACCCGC
GTACCGCAACACATCTGGAGGAATGGTTGCGCAAGCTCCGGCACGACCATCGCAATCGCATTCTTCCCATTACCGATCAG
ATTGCGGTCGAATGGGGGCGTATCGCGGCACAGCGACCGCGTGGTGACGCAGATGGGCTCATCGCGGCAACGGCGATCGT
TCATGACCTTATCGTCGTCACTCGCAACATCGGCGATTTCGACGACACCGGCGCCTTAATCGTCAACCCCTGGGATCAGA
AGCCTTACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12986.68 Da        Isoelectric Point: 4.4898

>AT153754 WP_044014553.1 NZ_CP051194:2478044-2478385 [Treponema sp. OMZ 855]
MMNYKGFIGVVEYDENARIFSGEVINTRTVITFQGTTVDEIEQEFHASVDDYLEWCKEDGVEPEKPYSGKFNVRISPLFH
SQVAIAAKKMDMSLNSFVEKSLKDEISTMRLTY

Download         Length: 342 bp

>AT153754 NZ_CP067071:2423670-2423924 [Rhizobium sp. AB2/73]
ATGAATTGGCCATTGCAGGATGCAAAGAATCAGTTTTCCAAAGTCGTACAGAAAGCACGTAGCGAAGGGCCGCAAATCGT
CACCTTGCGCGGCGAACCCGCGGCGGTCGTTCTGTCTGCCGAAGACTATGATGCACTTCTGGCTGGCAAACCGAGCCTTG
CCGATGATCTGCTGTCGGGGCCGGCTTGGGACGACGAAATAGCCGAAGCCGTATCTAAGCGAGATAAAACGCCAAGCCGG
GATGTCCTTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References