Detailed information of TA system TA153753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2186909..2187396
• Replicon: chromosome
• Accession: NZ_CP051194
• Organism: Treponema sp. OMZ 855

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N65_RS09895
• Protein ID: WP_253673076.1
• Coordinates: 2187130..2187396 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E4N65_RS09890
• Protein ID: WP_253673074.1
• Coordinates: 2186909..2187130 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N65_RS09860 (E4N65_09855)	2182583..2183371	-	789	WP_044014995.1	RNA polymerase sigma factor WhiG	-
E4N65_RS09865 (E4N65_09860)	2183392..2183997	-	606	WP_253673067.1	hypothetical protein	-
E4N65_RS09870 (E4N65_09865)	2184097..2184477	-	381	WP_253673068.1	MerR family transcriptional regulator	-
E4N65_RS09875 (E4N65_09870)	2184453..2185847	-	1395	WP_253674831.1	ribosome biogenesis GTPase Der	-
E4N65_RS09880 (E4N65_09875)	2186125..2186364	+	240	WP_253673070.1	DUF6364 family protein	-
E4N65_RS09885 (E4N65_09880)	2186357..2186776	+	420	WP_253673072.1	PIN domain-containing protein	-
E4N65_RS09890 (E4N65_09885)	2186909..2187130	+	222	WP_253673074.1	DUF6290 family protein	Antitoxin
E4N65_RS09895 (E4N65_09890)	2187130..2187396	+	267	WP_253673076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4N65_RS09900 (E4N65_09895)	2187732..2188046	+	315	WP_253673078.1	hypothetical protein	-
E4N65_RS09905 (E4N65_09900)	2188073..2189116	-	1044	WP_253673080.1	[citrate (pro-3S)-lyase] ligase	-
E4N65_RS09910 (E4N65_09905)	2189400..2189687	+	288	WP_253673082.1	citrate lyase acyl carrier protein	-
E4N65_RS09915 (E4N65_09910)	2189715..2190623	+	909	WP_253673084.1	aldolase/citrate lyase family protein	-
E4N65_RS09920 (E4N65_09915)	2190626..2192188	+	1563	WP_253673086.1	citrate lyase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10373.87 Da
• Isoelectric Point: 9.9931

>T153753 WP_253673076.1 NZ_CP051194:2187130-2187396 [Treponema sp. OMZ 855]
MYRVETTARFDKEFKKLDKYTQRMIAAWIDKNLEGSENPRVHGKGLTANRSGQWRYRIGDYRLICAIQDNELVILALTIG
HRRAVYDQ

Nucleotide

• Length: 267 bp

>T153753 NZ_CP067071:2423670-2423924 [Rhizobium sp. AB2/73]
ATGAATTGGCCATTGCAGGATGCAAAGAATCAGTTTTCCAAAGTCGTACAGAAAGCACGTAGCGAAGGGCCGCAAATCGT
CACCTTGCGCGGCGAACCCGCGGCGGTCGTTCTGTCTGCCGAAGACTATGATGCACTTCTGGCTGGCAAACCGAGCCTTG
CCGATGATCTGCTGTCGGGGCCGGCTTGGGACGACGAAATAGCCGAAGCCGTATCTAAGCGAGATAAAACGCCAAGCCGG
GATGTCCTTTTCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8175.26 Da
• Isoelectric Point: 5.1069

>AT153753 WP_253673074.1 NZ_CP051194:2186909-2187130 [Treponema sp. OMZ 855]
MAFSIRLTEAERAIANSYAKLHSVSLGEAFKNALFEKIEDEYDITVAAEAYQEYVSAGKKSRPFSELKKELGL

Nucleotide

• Length: 222 bp

>AT153753 NZ_CP067071:2423924-2424334 [Rhizobium sp. AB2/73]
ATGTATCTCGTCGATACCAACGTCGTCTCGGAACTCCGGCGCGGCAATTCCCAAGCGATTGCGTGGCTGCGCTCGGTCGA
TCCCTCCACCATTTATCTGAGTGTCATCACACTCGGAGAGATCATGCGTGGGATTGCGCTCAAGCGAAAATCGGACCCGC
GTACCGCAACACATCTGGAGGAATGGTTGCGCAAGCTCCGGCACGACCATCGCAATCGCATTCTTCCCATTACCGATCAG
ATTGCGGTCGAATGGGGGCGTATCGCGGCACAGCGACCGCGTGGTGACGCAGATGGGCTCATCGCGGCAACGGCGATCGT
TCATGACCTTATCGTCGTCACTCGCAACATCGGCGATTTCGACGACACCGGCGCCTTAATCGTCAACCCCTGGGATCAGA
AGCCTTACTGA