Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 913719..914298 Replicon chromosome
Accession NZ_CP051194
Organism Treponema sp. OMZ 855

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4N65_RS04165 Protein ID WP_044012884.1
Coordinates 913719..913910 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4N65_RS04170 Protein ID WP_044012882.1
Coordinates 913915..914298 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N65_RS04145 (E4N65_04125) 908974..910446 + 1473 WP_253674176.1 glycogen synthase GlgA -
E4N65_RS04150 (E4N65_04130) 910580..911050 + 471 WP_253674177.1 Cys-tRNA(Pro) deacylase -
E4N65_RS04155 (E4N65_04135) 911061..912713 - 1653 WP_044012887.1 nucleoside kinase -
E4N65_RS04165 (E4N65_04145) 913719..913910 + 192 WP_044012884.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N65_RS04170 (E4N65_04150) 913915..914298 + 384 WP_044012882.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N65_RS04175 (E4N65_04155) 914438..915949 - 1512 WP_253674182.1 MiaB/RimO family radical SAM methylthiotransferase -
E4N65_RS04180 (E4N65_04160) 915942..917060 - 1119 WP_044012875.1 helix-turn-helix domain-containing protein -
E4N65_RS04185 (E4N65_04165) 917098..917784 - 687 WP_044012871.1 outer membrane lipoprotein carrier protein LolA -
E4N65_RS04190 (E4N65_04170) 918188..918700 + 513 WP_044012867.1 TIGR03546 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-102)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7385.64 Da        Isoelectric Point: 10.2485

>T153752 WP_044012884.1 NZ_CP051194:913719-913910 [Treponema sp. OMZ 855]
MNFKEMEKMIKQDGWIKRDIVGSHHHYEHPIKKGKVTIPFHGNKELSKFVVNSILKQAGLKEE

Download         Length: 192 bp

>T153752 NZ_CP067071:c2252827-2252561 [Rhizobium sp. AB2/73]
ATGTTGCTTGCCTGGCACGCACATGCTTGGGAAGACTATTTATATTGGCGGGAAAGAGATCGTAAAATAGCTGTTAGAAT
CAACGAGCTTTTGCGGGACGCACTACGCCACCCGTTTGAGGGACTCGGCAAACCTGAGGCCCTGCGCAATCAACTCAAAG
GACAATGGTCGCGTCGCATCACGCAAGAGCACAGGCTGATTTACAAAGTCGAAGGTGAAGGCGATCGGCAAATACTTATC
GTTTTGCAATGTCGCTTCCACTATTAG

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14303.44 Da        Isoelectric Point: 4.3514

>AT153752 WP_044012882.1 NZ_CP051194:913915-914298 [Treponema sp. OMZ 855]
MYIYPAMFYKDENGYSVVFYDIELATMGDTLEEALIMAEEALTGRISLLLKDGETLPNPTAIEDIEKPKDAEFITLVKTD
RKYLAQEKSVRKNLTIPAWLAEAAENAGLNFSQELQCALKTRLHIGI

Download         Length: 384 bp

>AT153752 NZ_CP067071:c2253095-2252835 [Rhizobium sp. AB2/73]
ATGCGAACGGTCATGTTTTCAGCAGCACGAAATGAACTTGCTAGCTTGCTTGACGAAGTCGTGCAGGACCGTGTTGCCGT
GGAAATTGTTCGTCGCGATAAGCCGTCAGCCATTCTGATCGACAAGGAAGAATATGAAGGTATCATCGAGACGCTTCATG
TCCTGTCGACCCCGGCCAATGCGGCGCGGTTGATGGAAGCGATTACCGATGCAAACGAGGGAAAGAACCTCGTTTCTCAC
GATTTGATTGATCCGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References