Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2783970..2784484 Replicon chromosome
Accession NZ_CP051191
Organism Staphylococcus aureus strain NGA102

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag HF084_RS13860 Protein ID WP_000581793.1
Coordinates 2784275..2784484 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HF084_RS13855 Protein ID WP_000138932.1
Coordinates 2783970..2784263 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF084_RS13835 (2779334) 2779334..2779975 + 642 WP_000483164.1 thiamine phosphate synthase -
HF084_RS13840 (2780061) 2780061..2780933 + 873 WP_000725802.1 membrane protein insertase YidC -
HF084_RS13845 (2781645) 2781645..2782292 - 648 WP_001187627.1 HD domain-containing protein -
HF084_RS13850 (2782320) 2782320..2783804 - 1485 WP_000571552.1 cardiolipin synthase -
HF084_RS13855 (2783970) 2783970..2784263 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HF084_RS13860 (2784275) 2784275..2784484 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
HF084_RS13865 (2784612) 2784612..2784749 + 138 WP_000828354.1 Lmo0850 family protein -
HF084_RS13870 (2785012) 2785012..2786214 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
HF084_RS13875 (2786532) 2786532..2787602 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HF084_RS13880 (2787617) 2787617..2788975 + 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T153750 WP_000581793.1 NZ_CP051191:2784275-2784484 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T153750 NZ_CP067071:c723327-722962 [Rhizobium sp. AB2/73]
ATGATCCTGGTCGATACGTCGATCTGGATCGATCACTTTCATACGCCGGAGGCGCGGCTTCAATCTCTGCTGGAGCAAAA
ACAAGTCGTCGTTCATCCCTTTGTCGTTGGTGAGATCAGCCTTGGCAATCTGCGGCAATATGATCTCGTGATAGGAAGCC
TCCGTAGACTGCCTGCAATTGCGAGAGCCTCGGATGAGGACGTTCTTTATTTCATCCGAAGCAACAAACTGCAGGGTACG
GGAATCGGCTATATCGATGCCCATCTCGCGGCGGCCACGATACTGACGCCCGGAACCTATCTCTGGACGCGTGACAGGCG
GCTGCAACGAGTCGCCGAAAACCTCGGAATTGCCGCGCCGCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT153750 WP_000138932.1 NZ_CP051191:2783970-2784263 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT153750 NZ_CP067071:c723521-723324 [Rhizobium sp. AB2/73]
ATGCGCACTACCGTAGCCATCGATGACAAGTTGCTTGCGGATGCACGCGAGGTTACCGGTCTCGCCGAGACCTCGGCAAT
CCTACGTGAAGCATTGAAAGCCCTTGTGGAACGGGAAGCCGCCAAAACGCTGATACGTCTCGGCGGCACCGAACCGAATA
TCACGGCTCCCCCTCGTCGTCAGTTTGGCGTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References