Detailed information of TA system TA153730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): EcnAB/-
• Location: 4829848..4830233
• Replicon: chromosome
• Accession: NZ_CP051189
• Organism: Xanthomonas sp. GW

Toxin (Protein)

• Gene name: EcnB
• Uniprot ID: A0A0K2ZHE5
• Locus tag: HEP73_RS20900
• Protein ID: WP_003469322.1
• Coordinates: 4829848..4829982 (-)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: EcnA
• Uniprot ID: -
• Locus tag: HEP73_RS20905
• Protein ID: WP_185814371.1
• Coordinates: 4830081..4830233 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEP73_RS20880	4825919..4826842	-	924	WP_185821400.1	MBL fold metallo-hydrolase	-
HEP73_RS20885	4827121..4828413	-	1293	WP_185821401.1	tryptophan--tRNA ligase	-
HEP73_RS20890	4828562..4829356	+	795	WP_185823530.1	hypothetical protein	-
HEP73_RS20895	4829431..4829646	-	216	WP_145703764.1	CsbD family protein	-
HEP73_RS20900	4829848..4829982	-	135	WP_003469322.1	entericidin A/B family lipoprotein	Toxin
HEP73_RS20905	4830081..4830233	-	153	WP_185814371.1	entericidin A/B family lipoprotein	Antitoxin
HEP73_RS20910	4830377..4831300	-	924	WP_185821402.1	arginase	-
HEP73_RS20920	4831719..4832549	-	831	WP_185821403.1	SPOR domain-containing protein	-
HEP73_RS20925	4832559..4833299	-	741	WP_185821404.1	type III pantothenate kinase	-
HEP73_RS20930	4833296..4834291	-	996	WP_185821405.1	bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	-
HEP73_RS20935	4834428..4834700	+	273	WP_185821406.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-39)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4604.40 Da
• Isoelectric Point: 9.2977

>T153730 WP_003469322.1 NZ_CP051189:c4829982-4829848 [Xanthomonas sp. GW]
MKRTFAWMLLAMFSVGLLSGCNTVAGAGKDVKSAGEKVEDAAKN

Nucleotide

• Length: 135 bp

>T153730 NZ_CP067060:c4880921-4880637 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5305.33 Da
• Isoelectric Point: 7.5953

>AT153730 WP_185814371.1 NZ_CP051189:c4830233-4830081 [Xanthomonas sp. GW]
MKRLLTLMMLTLFCAGMLTGCNTMAGAGKDMQKAGDKVETKADDCSDGKC

Nucleotide

• Length: 153 bp

>AT153730 NZ_CP067060:c4881153-4880911 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0K2ZHE5