Detailed information of TA system TA153729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 3841554..3842059
• Replicon: chromosome
• Accession: NZ_CP051189
• Organism: Xanthomonas sp. GW

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HEP73_RS16400
• Protein ID: WP_046978179.1
• Coordinates: 3841802..3842059 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1C3TRJ9
• Locus tag: HEP73_RS16395
• Protein ID: WP_003468816.1
• Coordinates: 3841554..3841805 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEP73_RS16365	3837426..3837722	-	297	WP_185820789.1	hypothetical protein	-
HEP73_RS16370	3838499..3839104	-	606	WP_185823462.1	hypothetical protein	-
HEP73_RS16375	3839120..3839311	-	192	WP_185820790.1	hypothetical protein	-
HEP73_RS16380	3839350..3839793	-	444	WP_185820791.1	nuclear transport factor 2 family protein	-
HEP73_RS16385	3839917..3840639	+	723	WP_185820792.1	ArsR family transcriptional regulator	-
HEP73_RS16390	3840645..3841400	-	756	WP_185820793.1	endonuclease	-
HEP73_RS16395	3841554..3841805	+	252	WP_003468816.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HEP73_RS16400	3841802..3842059	+	258	WP_046978179.1	Txe/YoeB family addiction module toxin	Toxin
HEP73_RS16410	3842344..3842697	-	354	WP_003468813.1	PilZ domain-containing protein	-
HEP73_RS16415	3842694..3843671	-	978	WP_185820794.1	DNA polymerase III subunit delta'	-
HEP73_RS16420	3843668..3844336	-	669	WP_003479795.1	dTMP kinase	-
HEP73_RS16425	3844333..3845391	-	1059	WP_185820795.1	endolytic transglycosylase MltG	-
HEP73_RS16430	3845467..3846816	-	1350	WP_185820796.1	aminodeoxychorismate synthase component I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10173.68 Da
• Isoelectric Point: 9.6587

>T153729 WP_046978179.1 NZ_CP051189:3841802-3842059 [Xanthomonas sp. GW]
VTLQFSDNAWEDYLYWQQTDKKMLKRVNDLIKAIQRDPFQGVGKPEPLRHALAGYWSRRINDEHRIVYKVEAGILLIAQV
RYHYV

Nucleotide

• Length: 258 bp

>T153729 NZ_CP067060:c4718470-4717937 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9281.56 Da
• Isoelectric Point: 5.1186

>AT153729 WP_003468816.1 NZ_CP051189:3841554-3841805 [Xanthomonas sp. GW]
MDTITYSAARAALADTMERVVNNHEPVIITRSREQSVVMLSLEDYKAMEETAYLLRSPKSAQRLLESIAQLEAGRGKARD
LAE

Nucleotide

• Length: 252 bp

>AT153729 NZ_CP067060:c4718747-4718481 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C3TRJ9