Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3802541..3803187 Replicon chromosome
Accession NZ_CP051189
Organism Xanthomonas sp. GW

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HEP73_RS16245 Protein ID WP_185820769.1
Coordinates 3802541..3802954 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HEP73_RS16250 Protein ID WP_185813619.1
Coordinates 3802951..3803187 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP73_RS16225 3797642..3798289 - 648 WP_185820766.1 HAD family phosphatase -
HEP73_RS16230 3798312..3799379 - 1068 WP_185823460.1 MFS transporter -
HEP73_RS16235 3799827..3801152 - 1326 WP_185820767.1 ATP-binding protein -
HEP73_RS16240 3801139..3802530 - 1392 WP_185820768.1 sigma-54 dependent transcriptional regulator -
HEP73_RS16245 3802541..3802954 - 414 WP_185820769.1 type II toxin-antitoxin system VapC family toxin Toxin
HEP73_RS16250 3802951..3803187 - 237 WP_185813619.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HEP73_RS16255 3803284..3805722 - 2439 WP_185820770.1 ABC transporter permease -
HEP73_RS16260 3805719..3806489 - 771 WP_185820771.1 ABC transporter ATP-binding protein -
HEP73_RS16265 3806508..3807758 - 1251 WP_185820772.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

SpoVT-AbrB domain

(8-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.9954

>T153728 WP_185820769.1 NZ_CP051189:c3802954-3802541 [Xanthomonas sp. GW]
MSQPLYLLDTNICIYIINRRPPGVLDRFAALRIGQVAISSITGTELAYGVDKSGSPRNRQALDKFLAPLDILPFDEAAMR
RYGALRSGLERKGTPIGALDQLIAAHALAVDAVLVTNNVREFERVIGLRLENWVSTE

Download         Length: 414 bp

>T153728 NZ_CP067060:c4059266-4059048 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8991.29 Da        Isoelectric Point: 5.0976

>AT153728 WP_185813619.1 NZ_CP051189:c3803187-3802951 [Xanthomonas sp. GW]
MTTTAKLFQSGRSQAVRLPKALRFEGEEVIARRFGNGVLLLPLDAPWQLLREALEEFEPGFQLQREQPEQQVRGEWPV

Download         Length: 237 bp

>AT153728 NZ_CP067060:c4059667-4059293 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References