Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1652788..1654402 Replicon plasmid pUW576mp
Accession NZ_CP051176
Organism Ralstonia solanacearum strain Rs5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HF906_RS23285 Protein ID WP_119447938.1
Coordinates 1652788..1654131 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HF906_RS23290 Protein ID WP_119447937.1
Coordinates 1654136..1654402 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF906_RS23260 1648288..1649238 + 951 WP_094395472.1 LysR family transcriptional regulator -
HF906_RS23265 1649337..1649639 + 303 Protein_1312 MFS transporter -
HF906_RS23270 1649684..1650508 + 825 WP_094394930.1 IS5 family transposase -
HF906_RS23275 1650524..1651795 + 1272 Protein_1314 MFS transporter -
HF906_RS23280 1651804..1652700 - 897 WP_193010719.1 DUF2236 domain-containing protein -
HF906_RS23285 1652788..1654131 - 1344 WP_119447938.1 type II toxin-antitoxin system HipA family toxin Toxin
HF906_RS23290 1654136..1654402 - 267 WP_119447937.1 helix-turn-helix domain-containing protein Antitoxin
HF906_RS23295 1654572..1655477 + 906 WP_193010720.1 hypothetical protein -
HF906_RS23300 1655493..1655927 - 435 WP_094395823.1 PGDYG domain-containing protein -
HF906_RS23305 1656184..1656567 + 384 WP_013208661.1 VOC family protein -
HF906_RS23310 1656618..1657724 - 1107 WP_094395467.1 alpha/beta hydrolase -
HF906_RS23315 1657727..1658563 - 837 WP_119447935.1 AraC family transcriptional regulator -
HF906_RS23320 1658664..1659140 - 477 WP_042590720.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / fliI / fliM / flgG / flgC / cyaB / cheY / motA / cheW / cheB / cheY / adeG 1..1837383 1837383
- flank IS/Tn - - 1649753..1650508 755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49676.99 Da        Isoelectric Point: 9.0513

>T153723 WP_119447938.1 NZ_CP051176:c1654131-1652788 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEDRPLSRSLPFTPDNAPHRGPVVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLREQIGRDCIGALQVLPADMAPPATGDLDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGHFRIS
IAGAQEKTAFLQIDGRWYRPRGATPASHIFKLPMGLVGNMQLDLRESVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGKRLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLRAPAGHA
KNFSLALRPGGAYALTPLYDVMSAYPLLGKGPGKLSAHRIRLAMAIRSTNAHWKMQDILRRHWLGLGQRYGLVTSDGADA
ASIVDNLVARTPEVTRTVRAMLPEGFPQPLADSIRQGLQHAADKLAG

Download         Length: 1344 bp

>T153723 NZ_CP067060:327908-328276 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9620.18 Da        Isoelectric Point: 11.3760

>AT153723 WP_119447937.1 NZ_CP051176:c1654402-1654136 [Ralstonia solanacearum]
MNAFIVRTPEQLPAILKGFRKQAGLSQAELAARMGVRQQTLSALERNAENVSAARLMRLLSVLGVELVLRKPDAAGEPGR
PVSDQPQW

Download         Length: 267 bp

>AT153723 NZ_CP067060:327690-327911 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References