Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2122903..2124498 Replicon chromosome
Accession NZ_CP051173
Organism Ralstonia solanacearum strain UW763

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HF907_RS10000 Protein ID WP_064477776.1
Coordinates 2122903..2124240 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A9E8CGB2
Locus tag HF907_RS10005 Protein ID WP_064047703.1
Coordinates 2124244..2124498 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF907_RS09975 2118558..2119298 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
HF907_RS09980 2119295..2119993 + 699 WP_019718855.1 protocatechuate 3,4-dioxygenase subunit alpha -
HF907_RS09985 2120174..2120737 + 564 WP_080606483.1 RNA 2',3'-cyclic phosphodiesterase -
HF907_RS09990 2120750..2121478 - 729 WP_064477774.1 DsbA family protein -
HF907_RS09995 2121704..2122906 - 1203 WP_064477775.1 MFS transporter -
HF907_RS10000 2122903..2124240 - 1338 WP_064477776.1 type II toxin-antitoxin system HipA family toxin Toxin
HF907_RS10005 2124244..2124498 - 255 WP_064047703.1 helix-turn-helix transcriptional regulator Antitoxin
HF907_RS10010 2124601..2125440 - 840 WP_020831955.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
HF907_RS10015 2125758..2126396 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
HF907_RS10020 2126464..2126940 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
HF907_RS10025 2126960..2127511 + 552 WP_028860693.1 tRNA adenosine(34) deaminase TadA -
HF907_RS10030 2127508..2128434 + 927 WP_020831958.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-391)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48661.70 Da        Isoelectric Point: 6.7762

>T153717 WP_064477776.1 NZ_CP051173:c2124240-2122903 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMHACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVA
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T153717 NZ_CP067057:4472436-4472888 [Rahnella aceris]
GTGGCCCTGTGGCGATGTGATCTCAGGGTGTCCTGGCGCAGTCAGCTTATTTCACTGGGATGTTACGGTGCAGTGATGTT
GCTGATTTTGCTGGCACCCTGGCCTGCGGGTTACTGGCCGGTATGGATGACGTTGCTTTTGCTGGTGTTGTTTGAATGCA
TCCGCAGCCAGCGGCGTATTACAGCACGCACAGGTGAAATGATCCTGCTCGAGGATAACCGTCTTTTATGGCGCGGCCAT
GAATGGCAGATTAAACAGCCGGTATGGATGATAAGCCACGGCGTACTGCTCTCGCTTCGTCGCGAAAAACGTAAAGGCGG
GCTGGCGCAGGCGATGCGCAGTTCAAGGCAGCGGTTATGGCTGGCGTCGGACAGCATGAGTCTGGAAGAGTGGCGGCGGT
TGCGACAGATATTGCTCAGTGGCACTCCGCGTAGCCCGGTAAAACCGGGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8780.11 Da        Isoelectric Point: 10.0897

>AT153717 WP_064047703.1 NZ_CP051173:c2124498-2124244 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILYALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT153717 NZ_CP067057:4472189-4472455 [Rahnella aceris]
CTGGATATTAATAATCGTTCCCGCGTTCACTGGGCCTGCCGTCGTGGCATGCGCGAGCTGGATATCTCCATCATGCCGTT
CTTCGAATATGAATATGATTCGCTGAGCGAGACCGATAAAGAAGTATTTGTCCGCTTGCTGACCTGTGATGATCCGGATC
TGTTCAACTGGCTGATGAATCACGGCGAACCGAAAGACACCGAATTGCAGCGTATGGTCGCCCTTATTCAGACTCGAAAC
AAAGCCCGTGGCCCTGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References