Detailed information of TA system TA153716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1400324..1400985
• Replicon: chromosome
• Accession: NZ_CP051173
• Organism: Ralstonia solanacearum strain UW763

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HF907_RS06670
• Protein ID: WP_013211023.1
• Coordinates: 1400324..1400737 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q8Y121
• Locus tag: HF907_RS06675
• Protein ID: WP_011000825.1
• Coordinates: 1400734..1400985 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF907_RS06645	1395689..1395910	+	222	WP_064477637.1	hypothetical protein	-
HF907_RS06650	1395885..1396529	+	645	WP_064477634.1	hypothetical protein	-
HF907_RS06655	1396572..1396862	-	291	WP_011000820.1	H-NS histone family protein	-
HF907_RS06660	1397048..1398514	-	1467	WP_043876564.1	type III secretion system YopJ family effector PopP2	-
HF907_RS06665	1399125..1400252	+	1128	WP_193032737.1	DNA cytosine methyltransferase	-
HF907_RS06670	1400324..1400737	-	414	WP_013211023.1	type II toxin-antitoxin system VapC family toxin	Toxin
HF907_RS06675	1400734..1400985	-	252	WP_011000825.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HF907_RS06680	1401065..1405165	+	4101	WP_064477639.1	tape measure protein	-
HF907_RS06685	1405171..1405566	+	396	WP_064477640.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1375948..1415191	39243

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15605.94 Da
• Isoelectric Point: 5.7557

>T153716 WP_013211023.1 NZ_CP051173:c1400737-1400324 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLEDAVRRQNLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Nucleotide

• Length: 414 bp

>T153716 NZ_CP067057:c3736610-3736134 [Rahnella aceris]
ATGCACAATCAGGCCATGGAGATTAACGGATGGACCCTTCTCGCTCATCCTCTGATCCTGCAACAAATACAGGCACTCAC
TGATCAGGTTGTTTTACTGCGCCGCAAAGATCCGGCGGGCTATAAAAGTAAGAACGCCACCAAACGGCTGGCTGCGATCA
ATAAGCTGATGTTTGACGTTATCCCGCAGGATCCGGCGCGTGTTGAATTCCGTCAGGGCGATACGTTAGGCGGGGAATTC
TCACACTGGTTCAGGGCAAAATTCTTCCAGCAGTACCGTTTGTTTTTCCGCTACAACCTGAAAAGCCGGATCATTATTTA
CGCCTGGGTGAATGATGATAAAGAATTACGCGCCTACGAAAGCAAAACAGACGCATACCGGATGTTTCGCAAGATGTTGA
AAAGCGGTGAACCGCCAGACAACTGGCAGGCACTTTGCGAGGCGTCAGGGAAGGTAGCGGCGGAAGAATTCCCTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9335.52 Da
• Isoelectric Point: 5.0774

>AT153716 WP_011000825.1 NZ_CP051173:c1400985-1400734 [Ralstonia solanacearum]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGSGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Nucleotide

• Length: 252 bp

>AT153716 NZ_CP067057:c3736961-3736617 [Rahnella aceris]
ATGTCAGCCTCGGCACTATGGGGAATAAAATTCGAAGCCGAATCCAAAGTCACCCGCCGCTTCCAGACCACCATTCCGGC
CACTATCCGTAAGGCATTAAATCTCACCGAAAATGATCGGATCCAGTACAAGATTTTGCCAGACGGACAGGTGGTTATTT
CGAGGCAACTCGAAGAAGCGGAAGACCCTGTTATCAGTGCTTTTCTCGGTTTTGTGGCAAAAGATATGCTCAATAACCCG
GAAAATATGCAGCCGGTAACATTATCCCTGCATGAAAAAATCAATGTACTGACCGCCGGGATGGCTATCGATCTTGAGAG
CCCGCTTTCTGACGATGACGAGTAA

Structures

Antitoxin

• AlphaFold DB: Q8Y121