Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2223034..2224629 Replicon chromosome
Accession NZ_CP051171
Organism Ralstonia solanacearum strain RUN2279

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HF908_RS10360 Protein ID WP_193025710.1
Coordinates 2223292..2224629 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HF908_RS10355 Protein ID WP_020749234.1
Coordinates 2223034..2223288 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF908_RS10325 2219093..2220019 - 927 WP_064049931.1 muramoyltetrapeptide carboxypeptidase -
HF908_RS10330 2220016..2220567 - 552 WP_193025705.1 tRNA adenosine(34) deaminase TadA -
HF908_RS10335 2220587..2221063 - 477 WP_193025706.1 6-carboxytetrahydropterin synthase QueD -
HF908_RS10340 2221131..2221769 - 639 WP_193025707.1 7-carboxy-7-deazaguanine synthase -
HF908_RS10345 2221766..2221936 - 171 WP_193025708.1 hypothetical protein -
HF908_RS10350 2222091..2222930 + 840 WP_193025709.1 oxaloacetate decarboxylase -
HF908_RS10355 2223034..2223288 + 255 WP_020749234.1 helix-turn-helix transcriptional regulator Antitoxin
HF908_RS10360 2223292..2224629 + 1338 WP_193025710.1 type II toxin-antitoxin system HipA family toxin Toxin
HF908_RS10365 2224626..2225828 + 1203 WP_193025711.1 MFS transporter -
HF908_RS10370 2226054..2226782 + 729 WP_193025712.1 DsbA family protein -
HF908_RS10375 2226810..2227373 - 564 WP_193028497.1 RNA 2',3'-cyclic phosphodiesterase -
HF908_RS10380 2227554..2228252 - 699 WP_193025713.1 protocatechuate 3,4-dioxygenase subunit alpha -
HF908_RS10385 2228249..2228989 - 741 WP_193025714.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48831.87 Da        Isoelectric Point: 6.5034

>T153711 WP_193025710.1 NZ_CP051171:2223292-2224629 [Ralstonia solanacearum]
MAHPELHLWMNGEPVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFSLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDALLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLTAWGLEVAHTEMARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRTCLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLTDIHLRHWQALAAQSGVPDAFAGMLALVE
RVPAGLDQVEAILPHDFSGRVWSSVRTGVLAQTERFLTELASVTP

Download         Length: 1338 bp

>T153711 NZ_CP067057:c327620-327162 [Rahnella aceris]
TTGAAGCTGTTTCGTATCGTGCAGACCCGCCATCTGGCGACAGCCTGGTCGGGAGCCGGCGCGCAACTTTATGGCGGTCG
CTGGAATCCGCCAGGCAGGCCGGTCGTCTATGTCACCACCAGCATCTCACTGGCTATCCTGGAAATTCTGGTGCATTTGC
AAAACAGCATGCTGATGCGTTCCTATACCTTGCTGAGTATTGAGGTGCCAGAGGAACTGCTGGATACGCTGGAAGTTTCA
GAGCTTGCCGCCGACTGGCGAAGCGCATCGGTGCCTGACAGCACACAACGTCAGGGTGACGTCTGGCTTGCAGAAGGTGA
ATATGTCGGGCTGAAAGTGCCGTCAGTGATTGTGCCGTCGGAATACAACGTATTACTTAATCCGCTACACCCGGCTTTTG
CCGATTTACTGAGTTCAGTAGAACGCGAGCCCATGATGTTTGACCCGCGCCTGCAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8710.02 Da        Isoelectric Point: 10.4693

>AT153711 WP_020749234.1 NZ_CP051171:2223034-2223288 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGGPSAA
PADW

Download         Length: 255 bp

>AT153711 NZ_CP067057:c328078-327617 [Rahnella aceris]
ATGAATTCAAAAATTACCGGGCTGTCTTCCAGCTCTGTGCAAGATTCTGCAACGCCGCTTTGGCAATCTGCGGGCCTTCC
CGCAAGCAGCGGAATCAGTTTGATAAATGCCATACAAAAGGGATTTCCGGTTGATAGTATCAGCCGTCTTAATACTGAGC
TGGGATGGCCAAAAATGGTGTTACTGGAAATCATGGGCATTAACGAACGCAACTATGCCCGGCGTAAAGCCGGGAACGGA
TTGCTAAAAAGTGAAGAGAGTGAACGTGTGGCGCGACTGGTTCGCATCGTGGATGCCGCAACTGATTTGTTCGAAGGGGA
TCGTGTCTCGGCGCTCGAATGGTTCACCCGCCCTGCTCCGGCACTGGATGGTTCACGTCCGCTGGAACTGCTGTCTTCTG
AAGCGGGTGCTGTGGAAGTCAGCCGCCTGATTGGTCGTCTCCAGCACGGTGTTTTCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References