Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1063575..1064185 Replicon plasmid pUW774mp
Accession NZ_CP051170
Organism Ralstonia solanacearum strain RUN2474

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HF909_RS22305 Protein ID WP_193029203.1
Coordinates 1063877..1064185 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HF909_RS22300 Protein ID WP_016722339.1
Coordinates 1063575..1063880 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF909_RS22280 1058887..1059555 + 669 WP_193029797.1 hypothetical protein -
HF909_RS22285 1059669..1060634 + 966 WP_193035029.1 IS5 family transposase -
HF909_RS22290 1060867..1061853 + 987 WP_193026003.1 IS5 family transposase -
HF909_RS22295 1062049..1063362 - 1314 WP_193029205.1 metabolite/H+ symporter -
HF909_RS22300 1063575..1063880 - 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
HF909_RS22305 1063877..1064185 - 309 WP_193029203.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF909_RS22310 1064261..1065460 - 1200 WP_193036880.1 MFS transporter -
HF909_RS22315 1065587..1066402 - 816 WP_193029199.1 GntR family transcriptional regulator -
HF909_RS22320 1066580..1067131 - 552 WP_193029197.1 helix-turn-helix transcriptional regulator -
HF909_RS22325 1067264..1067857 + 594 WP_193029195.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / fliI / fliM / flgG / flgC / cyaB / motA / cheW / cheB / cheY / adeG 1..1942331 1942331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11783.57 Da        Isoelectric Point: 7.1355

>T153708 WP_193029203.1 NZ_CP051170:c1064185-1063877 [Ralstonia solanacearum]
MLTIRTTEIFDDWFCSLRDKAAQRRIQVRIDRLQMGNPGDMKAVRDGIRELRIDHGPGYRLYVVQHGVVLIVLLCGGDKS
TQEADIRRAIDLSRRLDVDDME

Download         Length: 309 bp

>T153708 NZ_CP067046:56036-56518 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT153708 WP_016722339.1 NZ_CP051170:c1063880-1063575 [Ralstonia solanacearum]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT153708 NZ_CP067046:55782-56048 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References