Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2190562..2192157 Replicon chromosome
Accession NZ_CP051169
Organism Ralstonia solanacearum strain RUN2474

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HF909_RS10490 Protein ID WP_193025710.1
Coordinates 2190820..2192157 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HF909_RS10485 Protein ID WP_020749234.1
Coordinates 2190562..2190816 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF909_RS10460 2185940..2186578 + 639 WP_193034637.1 phage tail protein I -
HF909_RS10465 2186594..2188171 + 1578 WP_193034638.1 phage tail protein -
HF909_RS10470 2188181..2188921 + 741 WP_193034639.1 phage tail protein -
HF909_RS10475 2188935..2189387 + 453 WP_193034640.1 hypothetical protein -
HF909_RS10480 2189619..2190458 + 840 WP_193025709.1 oxaloacetate decarboxylase -
HF909_RS10485 2190562..2190816 + 255 WP_020749234.1 helix-turn-helix transcriptional regulator Antitoxin
HF909_RS10490 2190820..2192157 + 1338 WP_193025710.1 type II toxin-antitoxin system HipA family toxin Toxin
HF909_RS10495 2192154..2193356 + 1203 WP_193025711.1 MFS transporter -
HF909_RS10500 2193582..2194310 + 729 WP_193034641.1 DsbA family protein -
HF909_RS10505 2194343..2194906 - 564 WP_193036749.1 RNA 2',3'-cyclic phosphodiesterase -
HF909_RS10510 2195087..2195785 - 699 WP_193034642.1 protocatechuate 3,4-dioxygenase subunit alpha -
HF909_RS10515 2195782..2196522 - 741 WP_193025714.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48831.87 Da        Isoelectric Point: 6.5034

>T153706 WP_193025710.1 NZ_CP051169:2190820-2192157 [Ralstonia solanacearum]
MAHPELHLWMNGEPVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFSLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDALLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLTAWGLEVAHTEMARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRTCLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLTDIHLRHWQALAAQSGVPDAFAGMLALVE
RVPAGLDQVEAILPHDFSGRVWSSVRTGVLAQTERFLTELASVTP

Download         Length: 1338 bp

>T153706 NZ_CP067045:c4953602-4952685 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8710.02 Da        Isoelectric Point: 10.4693

>AT153706 WP_020749234.1 NZ_CP051169:2190562-2190816 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGGPSAA
PADW

Download         Length: 255 bp

>AT153706 NZ_CP067045:c4954366-4953608 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGAGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References