Detailed information of TA system TA153705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1885519..1886172
• Replicon: chromosome
• Accession: NZ_CP051169
• Organism: Ralstonia solanacearum strain RUN2474

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HF909_RS09165
• Protein ID: WP_193034500.1
• Coordinates: 1885987..1886172 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0S4XBS4
• Locus tag: HF909_RS09160
• Protein ID: WP_028853163.1
• Coordinates: 1885519..1885920 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF909_RS09115	1881070..1881342	+	273	WP_193034493.1	hypothetical protein	-
HF909_RS09120	1881342..1882013	+	672	WP_020748501.1	hypothetical protein	-
HF909_RS09125	1882092..1882583	+	492	WP_193034494.1	glycoside hydrolase family protein	-
HF909_RS09130	1882583..1882891	+	309	WP_193034495.1	hypothetical protein	-
HF909_RS09135	1882894..1883169	+	276	WP_193034496.1	hypothetical protein	-
HF909_RS09140	1883169..1883714	+	546	WP_193034497.1	lysis protein	-
HF909_RS09145	1883832..1884023	-	192	WP_193034498.1	hypothetical protein	-
HF909_RS09150	1884020..1884589	-	570	WP_193034499.1	hypothetical protein	-
HF909_RS09155	1884698..1885267	-	570	Protein_1797	LysM peptidoglycan-binding domain-containing protein	-
HF909_RS09160	1885519..1885920	-	402	WP_028853163.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HF909_RS09165	1885987..1886172	-	186	WP_193034500.1	type II toxin-antitoxin system HicA family toxin	Toxin
HF909_RS09170	1886604..1886798	+	195	WP_193025429.1	hypothetical protein	-
HF909_RS09175	1887041..1889050	+	2010	WP_193025431.1	bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC	-
HF909_RS09180	1889284..1890633	+	1350	WP_193034501.1	trigger factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1845190..1900536	55346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6915.06 Da
• Isoelectric Point: 10.8224

>T153705 WP_193034500.1 NZ_CP051169:c1886172-1885987 [Ralstonia solanacearum]
MQSAQLIRMLEDDGWQLVRVNGSHHHYKHPERPGLLTVPHPKKDLPIGTVRSIQKKAAGLK

Nucleotide

• Length: 186 bp

>T153705 NZ_CP067045:c4683404-4682871 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14752.56 Da
• Isoelectric Point: 4.4190

>AT153705 WP_028853163.1 NZ_CP051169:c1885920-1885519 [Ralstonia solanacearum]
MQFPIAIHKDEGSVYGVTVPDIPGVHSWGDTIDDAVRNTREAIAGHLQTLVELGEDVDVTCSTIEDLTKQDEYAGAVWAL
IDVDAEELDRTPERINVSLPRFVLKKLDRFAENRHETRSGLLARAAMELMAHG

Nucleotide

• Length: 402 bp

>AT153705 NZ_CP067045:c4683681-4683415 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S4XBS4