Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1136506..1137050 Replicon chromosome
Accession NZ_CP051169
Organism Ralstonia solanacearum strain RUN2474

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HF909_RS05470 Protein ID WP_193036060.1
Coordinates 1136506..1136781 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HF909_RS05475 Protein ID WP_193027891.1
Coordinates 1136781..1137050 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF909_RS05440 1132619..1133935 + 1317 WP_193036054.1 serine--tRNA ligase -
HF909_RS05450 1134159..1134722 + 564 WP_193027888.1 recombinase family protein -
HF909_RS05455 1134700..1135068 - 369 WP_193036056.1 DUF2726 domain-containing protein -
HF909_RS05460 1135117..1135260 - 144 WP_193036058.1 hypothetical protein -
HF909_RS05465 1135475..1136437 - 963 WP_193026670.1 IS5 family transposase -
HF909_RS05470 1136506..1136781 - 276 WP_193036060.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF909_RS05475 1136781..1137050 - 270 WP_193027891.1 ribbon-helix-helix domain-containing protein Antitoxin
HF909_RS05480 1137097..1137327 - 231 WP_193036062.1 hypothetical protein -
HF909_RS05485 1137396..1138184 - 789 WP_193034608.1 IS21-like element ISRso19 family helper ATPase IstB -
HF909_RS05490 1138181..1139197 - 1017 WP_193027114.1 IS21 family transposase -
HF909_RS05495 1139547..1139765 - 219 Protein_1078 NAD(P)H-dependent oxidoreductase -
HF909_RS05500 1139956..1140735 - 780 WP_193035962.1 alpha/beta hydrolase -
HF909_RS05505 1140867..1141766 + 900 WP_193035960.1 LysR family transcriptional regulator -
HF909_RS05510 1141756..1142007 - 252 WP_193035958.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1124966..1190824 65858
- inside IScluster/Tn - - 1135475..1139197 3722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10688.36 Da        Isoelectric Point: 9.8943

>T153704 WP_193036060.1 NZ_CP051169:c1136781-1136506 [Ralstonia solanacearum]
MEVKWTGKAVSDITRLYEFLSQVNKPAAIRVVQSLTGAPKSLVVNPRIGEQLDEFEPREVRRIIVGQYEMRYEIRGSVIY
VLRLWHTREDR

Download         Length: 276 bp

>T153704 NZ_CP067045:4087647-4087865 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10056.37 Da        Isoelectric Point: 6.7268

>AT153704 WP_193027891.1 NZ_CP051169:c1137050-1136781 [Ralstonia solanacearum]
MAHLDTRVLTAHVPVQLAERVDQIAERLERSRGWIMKQALSAWIDQEEERSRLTREALADVDAGTVIDHQAVQAWADSLS
TSKPKKAPR

Download         Length: 270 bp

>AT153704 NZ_CP067045:4087246-4087620 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References