Detailed information of TA system TA153701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4236535..4237139
• Replicon: chromosome
• Accession: NZ_CP051168
• Organism: [Phormidium] sp. ETS-05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HEQ85_RS18565
• Protein ID: WP_199246115.1
• Coordinates: 4236535..4236921 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HEQ85_RS18570
• Protein ID: WP_199246116.1
• Coordinates: 4236918..4237139 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEQ85_RS18550	4231662..4232264	-	603	WP_199250483.1	CDP-alcohol phosphatidyltransferase family protein	-
HEQ85_RS18555	4232492..4234006	-	1515	WP_199250484.1	NADH-quinone oxidoreductase subunit M	-
HEQ85_RS18560	4234134..4235981	-	1848	WP_199246114.1	NAD(P)H-quinone oxidoreductase subunit F	-
HEQ85_RS18565	4236535..4236921	-	387	WP_199246115.1	type II toxin-antitoxin system VapC family toxin	Toxin
HEQ85_RS18570	4236918..4237139	-	222	WP_199246116.1	DUF2281 domain-containing protein	Antitoxin
HEQ85_RS18575	4237811..4238086	+	276	Protein_3666	hypothetical protein	-
HEQ85_RS18580	4238213..4238392	+	180	WP_199246117.1	hypothetical protein	-
HEQ85_RS18585	4238396..4241137	-	2742	WP_199246118.1	valine--tRNA ligase	-
HEQ85_RS18590	4241506..4242135	+	630	WP_199250485.1	DUF488 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-127)

Antitoxin

• Domain of unknown function DUF2281 (5-71)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14637.85 Da
• Isoelectric Point: 5.8844

>T153701 WP_199246115.1 NZ_CP051168:c4236921-4236535 [[Phormidium] sp. ETS-05]
MSKFLLDTHTFIWFVSNDAKLPESTRNQIESADAVFLSIVSIWEIAIKLSIGKLHLQGDFEEIEPQLITAGITMLNITFS
DTVHYRYLPLHHGDPFDRMLIAQAINHGLVLVSRDRAFDPYPVTRLWG

Nucleotide

• Length: 387 bp

>T153701 NZ_CP067045:1920050-1920152 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8481.77 Da
• Isoelectric Point: 4.4915

>AT153701 WP_199246116.1 NZ_CP051168:c4237139-4236918 [[Phormidium] sp. ETS-05]
METDILMTVSQLPEALKQEVLHYAEFLAEKHKNTLVPDNPEKKRRAGTMKGMFVLPLPDDFDEPLEEFKEYMG

Nucleotide

• Length: 222 bp

>AT153701 NZ_CP067045:c1920159-1920014 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT