Detailed information of TA system TA153700

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3596033..3596918
• Replicon: chromosome
• Accession: NZ_CP051168
• Organism: [Phormidium] sp. ETS-05

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: HEQ85_RS15550
• Protein ID: WP_199245410.1
• Coordinates: 3596478..3596918 (+)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: HEQ85_RS15545
• Protein ID: WP_199245409.1
• Coordinates: 3596033..3596488 (+)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEQ85_RS15530	3592246..3593118	-	873	WP_199245406.1	WYL domain-containing protein	-
HEQ85_RS15535	3593241..3595421	+	2181	WP_199245407.1	type I-D CRISPR-associated helicase Cas3'	-
HEQ85_RS15540	3595744..3595932	+	189	WP_199245408.1	hypothetical protein	-
HEQ85_RS15545	3596033..3596488	+	456	WP_199245409.1	nucleotidyltransferase domain-containing protein	Antitoxin
HEQ85_RS15550	3596478..3596918	+	441	WP_199245410.1	DUF86 domain-containing protein	Toxin
HEQ85_RS15555	3596911..3600417	+	3507	WP_199245411.1	type I-D CRISPR-associated protein Cas10d/Csc3	-
HEQ85_RS15560	3600605..3601618	+	1014	WP_199245412.1	type I-D CRISPR-associated protein Cas7/Csc2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (15-125)

Antitoxin

• Polymerase beta, nucleotidyltransferase (20-111)

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16680.25 Da
• Isoelectric Point: 4.9246

>T153700 WP_199245410.1 NZ_CP051168:3596478-3596918 [[Phormidium] sp. ETS-05]
MTIEKYIVIAKIDLMGKYLERLQRFESVTLEQYLNDGDMQLVVERLLQLIIQMAIDLNRYFLKELGIDQPETNAEAFHAV
SQCGIIPDNLAKNIAGSVSLQNRLVHGYDTIDSVIVHGSIKKVLQYFPMYQKQVGNYLDSLEDKNG

Nucleotide

• Length: 441 bp

>T153700 NZ_CP067045:1731726-1732058 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 17274.47 Da
• Isoelectric Point: 4.9960

>AT153700 WP_199245409.1 NZ_CP051168:3596033-3596488 [[Phormidium] sp. ETS-05]
MNTGAEKSTDITNLAVQLPEKFQHLKMLVLFGSRARGDFRPNSDWDFAAVYDEAIYQNLTENPFAVFEISGIISNLLNIP
ESKIDVIDLGRCSALLAHYVARDGKVLYEQEPGQFEQFRRQALKSHAEMKATYQSLRAKLDERLQNWGYDD

Nucleotide

• Length: 456 bp

>AT153700 NZ_CP067045:1731468-1731725 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA