Detailed information of TA system TA153699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1246088..1247119
• Replicon: chromosome
• Accession: NZ_CP051168
• Organism: [Phormidium] sp. ETS-05

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: HEQ85_RS05555
• Protein ID: WP_199248653.1
• Coordinates: 1246490..1247119 (+)
• Length: 210 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: HEQ85_RS05550
• Protein ID: WP_199250222.1
• Coordinates: 1246088..1246486 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEQ85_RS05535	1242630..1243208	+	579	WP_199248650.1	recombination mediator RecR	-
HEQ85_RS05540	1243420..1244985	+	1566	WP_199248651.1	hypothetical protein	-
HEQ85_RS05545	1245042..1245899	+	858	WP_199248652.1	hypothetical protein	-
HEQ85_RS05550	1246088..1246486	+	399	WP_199250222.1	helix-turn-helix domain-containing protein	Antitoxin
HEQ85_RS05555	1246490..1247119	+	630	WP_199248653.1	PIN domain-containing protein	Toxin
HEQ85_RS05560	1247076..1248044	+	969	Protein_1091	DUF262 domain-containing protein	-
HEQ85_RS05565	1248060..1248575	+	516	Protein_1092	DUF29 family protein	-
HEQ85_RS05570	1248748..1249727	-	980	Protein_1093	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• SinI-like, DNA-binding domain (61-107)

Sequences

Toxin

Protein

• Length: 210 a.a.
• Molecular weight: 24405.83 Da
• Isoelectric Point: 6.8355

>T153699 WP_199248653.1 NZ_CP051168:1246490-1247119 [[Phormidium] sp. ETS-05]
MGSNFTVLYDACVLYPAPLRDFLMELACTGLFRARWTDQIHDEWIQNLLQNRSDLTQEQLNRTRTLMNRSVPNSLITGYE
WMINSLQLPDPNDRHVLAAAIQGRVDAIVTFNLKDFPQSILDTHGIESLHPNEFITDLIDLSPLAVAEAARTCHQRLKNP
PTSREEYLQISKPKDSRVPSLSYRNYFIKFIKIPFHDEKLTRYPHYQFW

Nucleotide

• Length: 630 bp

>T153699 NZ_CP067045:840324-840734 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 15102.48 Da
• Isoelectric Point: 4.9801

>AT153699 WP_199250222.1 NZ_CP051168:1246088-1246486 [[Phormidium] sp. ETS-05]
MLAKYLRQQRQDQKLKMVVVEEDGSESVVEIPAIALQLLGEILMQMARGNAVTLIPIHAELTTQEAADLLNVSRPYLIQL
LESGEIPFHKVGRHRRIKFQDLMNYKEEIDRQRMAALDELAAQAQELNMGYD

Nucleotide

• Length: 399 bp

>AT153699 NZ_CP067045:840077-840343 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA