Detailed information of TA system TA153698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1184491..1184945
• Replicon: chromosome
• Accession: NZ_CP051168
• Organism: [Phormidium] sp. ETS-05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HEQ85_RS05290
• Protein ID: WP_199248613.1
• Coordinates: 1184742..1184945 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HEQ85_RS05285
• Protein ID: WP_199248612.1
• Coordinates: 1184491..1184745 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEQ85_RS05245	1179750..1180994	+	1245	WP_199248606.1	transposase	-
HEQ85_RS05250	1181290..1181577	+	288	WP_054466246.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HEQ85_RS05255	1181699..1182010	+	312	WP_199248607.1	HigA family addiction module antidote protein	-
HEQ85_RS05260	1182169..1182342	+	174	WP_199248608.1	hypothetical protein	-
HEQ85_RS05265	1182363..1182605	-	243	WP_199248609.1	type II toxin-antitoxin system VapB family antitoxin	-
HEQ85_RS05270	1182710..1183237	+	528	Protein_1033	DUF29 domain-containing protein	-
HEQ85_RS05275	1183745..1184044	-	300	WP_199248610.1	hypothetical protein	-
HEQ85_RS05280	1184229..1184366	-	138	WP_199248611.1	hypothetical protein	-
HEQ85_RS05285	1184491..1184745	+	255	WP_199248612.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HEQ85_RS05290	1184742..1184945	+	204	WP_199248613.1	Txe/YoeB family addiction module toxin	Toxin
HEQ85_RS05295	1185553..1186005	-	453	WP_199248614.1	DUF29 domain-containing protein	-
HEQ85_RS05300	1186275..1187312	+	1038	WP_199248615.1	glycosyltransferase family 4 protein	-
HEQ85_RS05305	1187382..1188020	+	639	WP_199250217.1	hypothetical protein	-
HEQ85_RS05310	1188041..1188505	+	465	WP_199248616.1	DUF29 domain-containing protein	-
HEQ85_RS05315	1188704..1189195	+	492	Protein_1042	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-67)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7972.29 Da
• Isoelectric Point: 10.0964

>T153698 WP_199248613.1 NZ_CP051168:1184742-1184945 [[Phormidium] sp. ETS-05]
MKISFTEASWSDYLWLQANEQKLLKRVNLLIKDIIITPFDWIGKPEPLKGNLSGYWSRRINTEHRLV

Nucleotide

• Length: 204 bp

>T153698 NZ_CP067045:347818-348186 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9485.76 Da
• Isoelectric Point: 4.3085

>AT153698 WP_199248612.1 NZ_CP051168:1184491-1184745 [[Phormidium] sp. ETS-05]
MKAITSNQAKQQLDEIIEQVILDVEPTILCSDRGQQAVLMSLDEFNSWQETIYLLSNPANAEHLLESIKQAKSGKKSVRE
LLDE

Nucleotide

• Length: 255 bp

>AT153698 NZ_CP067045:347600-347821 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA