Detailed information of TA system TA153695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /PIN(toxin)
• Location: 276559..277210
• Replicon: chromosome
• Accession: NZ_CP051168
• Organism: [Phormidium] sp. ETS-05

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HEQ85_RS01325
• Protein ID: WP_199247980.1
• Coordinates: 276559..276966 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HEQ85_RS01330
• Protein ID: WP_199247981.1
• Coordinates: 276950..277210 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEQ85_RS01295	271963..272694	-	732	WP_199247976.1	Uma2 family endonuclease	-
HEQ85_RS01300	272726..274773	-	2048	Protein_258	DEAD/DEAH box helicase	-
HEQ85_RS01305	274770..274934	-	165	WP_199247977.1	hypothetical protein	-
HEQ85_RS01310	275019..275225	+	207	WP_199247978.1	DUF433 domain-containing protein	-
HEQ85_RS01315	275220..275636	-	417	WP_199250118.1	PIN domain-containing protein	-
HEQ85_RS01320	276144..276380	-	237	WP_199247979.1	hypothetical protein	-
HEQ85_RS01325	276559..276966	-	408	WP_199247980.1	PIN domain-containing protein	Toxin
HEQ85_RS01330	276950..277210	-	261	WP_199247981.1	DUF2281 domain-containing protein	Antitoxin
HEQ85_RS01335	277569..277982	-	414	WP_199247982.1	PIN domain-containing protein	-
HEQ85_RS01340	277979..278254	-	276	WP_199247983.1	DUF2281 domain-containing protein	-
HEQ85_RS01345	278566..278946	-	381	WP_199247984.1	HEPN domain-containing protein	-
HEQ85_RS01350	278943..279263	-	321	WP_199247985.1	nucleotidyltransferase domain-containing protein	-
HEQ85_RS01355	279266..282071	-	2806	Protein_269	class I SAM-dependent DNA methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-114)

Antitoxin

• Domain of unknown function DUF2281 (6-69)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14857.18 Da
• Isoelectric Point: 4.2290

>T153695 WP_199247980.1 NZ_CP051168:c276966-276559 [[Phormidium] sp. ETS-05]
VKILIDPNIVLDLILEREPFVERAIALFEQIERGNLAGYIAATSITNIFYIIRKTEGIEVALAAITQLLKGLGFCAVDRH
TVETALSLGLQDFEDSIQLACAIQNQLDGIVTRDGKDFIGSNLPIYSPTELLNQI

Nucleotide

• Length: 408 bp

>T153695 NZ_CP067042:c2546134-2545751 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGTAACCG
GCCCGTACTTATTATTCAAAACAATGTTGGTAACCATTATAGCCCCACTGTTATCGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGCTACAGGCACGCGTTACCGCTCTCTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9570.75 Da
• Isoelectric Point: 4.7023

>AT153695 WP_199247981.1 NZ_CP051168:c277210-276950 [[Phormidium] sp. ETS-05]
MTAAEKLYQLLQTLPESQINEVLHFAEFLQQKQLISPQQVIPSGTLTGLRGIAKRPAPAPSDGELQAEYTDYLSQKTSKP
DRENSD

Nucleotide

• Length: 261 bp

>AT153695 NZ_CP067042:c2546402-2546154 [Lacticaseibacillus rhamnosus]
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGATAGTGCTATCAAAGCGCGTTTGGATGCCTATTGCGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAATTGATTT
CTGGCTATGTGGCAATGGGACAAATCAATACGGAAATCAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA