Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4161152..4161743 Replicon chromosome
Accession NZ_CP051167
Organism Oxynema sp. AP17

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HCG48_RS16845 Protein ID WP_168570194.1
Coordinates 4161369..4161743 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HCG48_RS16840 Protein ID WP_168570193.1
Coordinates 4161152..4161376 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCG48_RS16825 4157405..4158334 - 930 WP_168570191.1 CoA-binding protein -
HCG48_RS16830 4158389..4159627 - 1239 WP_168570192.1 succinate--CoA ligase subunit beta -
HCG48_RS16835 4160219..4160359 - 141 Protein_3286 transposase -
HCG48_RS25535 4160775..4160945 + 171 WP_210437059.1 hypothetical protein -
HCG48_RS16840 4161152..4161376 + 225 WP_168570193.1 hypothetical protein Antitoxin
HCG48_RS16845 4161369..4161743 + 375 WP_168570194.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HCG48_RS16850 4161839..4162198 - 360 WP_168567322.1 hypothetical protein -
HCG48_RS16855 4162200..4162427 - 228 WP_210437060.1 transposase -
HCG48_RS16860 4162437..4162988 + 552 WP_210437061.1 hypothetical protein -
HCG48_RS16865 4162961..4163575 - 615 WP_210437275.1 transposase -
HCG48_RS16870 4163577..4164161 - 585 WP_168570195.1 helix-turn-helix domain-containing protein -
HCG48_RS16875 4164411..4166252 + 1842 WP_168570196.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14023.04 Da        Isoelectric Point: 7.3221

>T153693 WP_168570194.1 NZ_CP051167:4161369-4161743 [Oxynema sp. AP17]
MPNGHLTYKRGEIWWVDLHPVLGHETDKKRPCLILQNDIGNQNGATTIVAPLLPGARTYPFVVNVTPTAKNGLDKDRHIN
LSQMRAVDAQRIKNKQGDLEESYWEKIEEAVCIELGFSLAFRSL

Download         Length: 375 bp

>T153693 NZ_CP067041:3606152-3606505 [Bradyrhizobium diazoefficiens]
TTGGCAACGAAGCCTGGTGACTATTGTCCCGAGGCCGGGGATGTCATCTGGATCGATCTGGACCCGACGGTCGGACACGA
ACAGAGCGGCCGACGACCGGCCATGGTCGTGTCGCCGCGGAGTTACAATACCGTCGCCGGCCTTTGCGTCATCTGCCCGA
TCACCAGTCGCGTGCGCGGTTATCCGTTCGAAGCCGTCCTGCCAGAAGGTGCAAGCGTCCGTGGCGTCGTGCTTGCAGAC
CAGCCCCGGAGTATCTCCTGGGAGCTACGACCGATCACGCCTGCCGGACGGGCGCCTGACGCGCTGCTCCTCGAAGTCCG
CGAACGGTTGGCTGCGTTGCTTGGAATTGATTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8589.61 Da        Isoelectric Point: 4.1964

>AT153693 WP_168570193.1 NZ_CP051167:4161152-4161376 [Oxynema sp. AP17]
MSKKVSITLDDEILEFVDRLASNRSSFINNILWQEKRRIFMKELEDAYKDQANDPELQQEISAWDVTVGDGLNA

Download         Length: 225 bp

>AT153693 NZ_CP067041:3605917-3606171 [Bradyrhizobium diazoefficiens]
ATGAAGGTTGCATTTCAGAAGTGGGGCAACAGCCTCGCGCTACGCATACCGAAAGCGTTTGCCGATGAAATCGGAGCCCG
CGACGGGAGGGCCGCGGAGATGACCGTGAGCGACGGCAAGCTGGTCATCGAGATCGCGCGTGCGCAGCGGCGCAAACGCC
GCTATGCGCTCGACGATCTGGTCGCTGGGATCACGCCGGCCAACCGTCACGATGAGACCGATTGGGGGCCGGCCGTTGGC
AACGAAGCCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References