Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 3260533..3261110 Replicon chromosome
Accession NZ_CP051167
Organism Oxynema sp. AP17

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HCG48_RS13275 Protein ID WP_168569583.1
Coordinates 3260533..3260862 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HCG48_RS13280 Protein ID WP_168569584.1
Coordinates 3260850..3261110 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCG48_RS13250 3256021..3257409 + 1389 WP_210437028.1 asparagine--tRNA ligase -
HCG48_RS13255 3257506..3257895 - 390 WP_168569580.1 type II toxin-antitoxin system VapC family toxin -
HCG48_RS13260 3257885..3258118 - 234 WP_008055509.1 hypothetical protein -
HCG48_RS13265 3258220..3258414 - 195 WP_168569581.1 hypothetical protein -
HCG48_RS13270 3258559..3260442 - 1884 WP_168569582.1 HEAT repeat domain-containing protein -
HCG48_RS13275 3260533..3260862 - 330 WP_168569583.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HCG48_RS13280 3260850..3261110 - 261 WP_168569584.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HCG48_RS25475 3261221..3262249 - 1029 WP_210437260.1 NACHT domain-containing protein -
HCG48_RS25480 3262575..3262876 - 302 Protein_2595 hypothetical protein -
HCG48_RS13290 3263223..3263924 - 702 WP_168569586.1 DUF4336 domain-containing protein -
HCG48_RS13295 3264007..3265971 - 1965 WP_168569587.1 ATP-dependent zinc metalloprotease FtsH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

SpoVT-AbrB domain

(10-51)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12102.14 Da        Isoelectric Point: 7.8292

>T153691 WP_168569583.1 NZ_CP051167:c3260862-3260533 [Oxynema sp. AP17]
MGVVAQRFDVFLVNLDPTIGSEIQKTRPCVIISPDEMNRHIATVIIAPMTTKGKAYPTRIACQFQGKEGKIVLDQIRTID
KTRLVKKLGQISPDEQSGVLDTLAEMFSE

Download         Length: 330 bp

>T153691 NZ_CP067037:611686-612045 [Agrobacterium fabrum]
ATGGTCCGCAACCAGATCCCCAAGCGCGGCGACGTTTATCTGGTTGATCTAAACCCTGTCGTAGGCAGCGAAATCAAGGA
CGAACATCGCTGTGTCGTCATCACGCCCAGAGAAATTAACGCGGTCGGACTCTGTCTCGTCGTCCCGGTGACCACCGGCG
GCATGTTTACGCGCAAGGCAGGGCTTGCCGTAAATATATCCGGCCACAAGACAACGGGCGTCGCTTTGTGCAATCAGGTG
AGAAGCATGGATATCGTCGCCCGGGTTGCCCAGAAGAAAGCGAAATATATCGAAACCCTCGATGATGCGACGATCGATGA
AATCGCCGGGCGCGTCATCAGCATGATCGATCCAGCTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9970.23 Da        Isoelectric Point: 4.6310

>AT153691 WP_168569584.1 NZ_CP051167:c3261110-3260850 [Oxynema sp. AP17]
MSTVIRTRIVKIGNSQGVRIPKLLLEQSGIQTDVEIEVEGDRLTIRTARRLRNGWDQAFAAMAKEQDDVLLDRVNSTDWE
QSEWEW

Download         Length: 261 bp

>AT153691 NZ_CP067037:611420-611686 [Agrobacterium fabrum]
ATGACCGTGACCACGAAAATAAGACGCCAGGGCGGCGCGGCGGTGATGACGATCCCGCCCGCTCTTTTGAAGATGCTGGG
GCTGGAAATCGGTGAGCAACTGACGCTCGAGGTCGATAATGGCGCTCTGGTGGCAAGCCCGGTTCGACTGGAAAAGAAAC
GCTTCACGCTGGCCGAATTACTGGATGGTGCAGAGGAAGTGGCAGCTCTAAACGCCAGGGAGCGGGCGTGGGACACAGCG
CCTCCTGTCGGCAAAGAAGCGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References