Detailed information of TA system TA153689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2728120..2728893
• Replicon: chromosome
• Accession: NZ_CP051165
• Organism: Staphylococcus aureus strain NGA84b

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: HF584_RS13400
• Protein ID: WP_054189550.1
• Coordinates: 2728744..2728893 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0D1IYN8
• Locus tag: HF584_RS13395
• Protein ID: WP_001251219.1
• Coordinates: 2728120..2728719 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF584_RS13375 (2724036)	2724036..2725493	+	1458	WP_054189548.1	ABC transporter permease subunit	-
HF584_RS13380 (2725486)	2725486..2726208	+	723	WP_054189583.1	amino acid ABC transporter ATP-binding protein	-
HF584_RS13385 (2726359)	2726359..2727486	+	1128	WP_054189549.1	tRNA epoxyqueuosine(34) reductase QueG	-
HF584_RS13390 (2727491)	2727491..2727961	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
HF584_RS13395 (2728120)	2728120..2728719	+	600	WP_001251219.1	glucosamine-6-phosphate isomerase	Antitoxin
HF584_RS13400 (2728744)	2728744..2728893	+	150	WP_054189550.1	SAS053 family protein	Toxin
HF584_RS13405 (2729558)	2729558..2729953	+	396	WP_000901023.1	hypothetical protein	-
HF584_RS13410 (2730149)	2730149..2731534	+	1386	WP_054189551.1	class II fumarate hydratase	-
HF584_RS13415 (2732001)	2732001..2732822	-	822	WP_249740041.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5862.20 Da
• Isoelectric Point: 3.9075

>T153689 WP_054189550.1 NZ_CP051165:2728744-2728893 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVNDFEDLKELGKEMEQISDQNEQEKNSEEDN

Nucleotide

• Length: 150 bp

>T153689 NZ_CP067037:c352980-352711 [Agrobacterium fabrum]
GTGATCTGGACAATTGAATATCACACGCTTGTGCAGAAAGAGATGCGCAAAATAAATCCGGAAGTGCGCCGGCGCATCCG
CAGTTTTCTCCATGAAAGGCTGGCCGCACTGGACGACCCGCGCCAGATCGGCGCTACACTGCAAGGTTCCGAACTCGGAA
ATTTCTGGCGTTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGACCAAAAGCTGGTCGTTCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATTTACCGTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22357.50 Da
• Isoelectric Point: 5.1445

>AT153689 WP_001251219.1 NZ_CP051165:2728120-2728719 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT153689 NZ_CP067037:c353191-352964 [Agrobacterium fabrum]
ATGAGCAAACAGACGGCCATTCGCCTGCCGGACGAGACCTATGAGCGGCTGAAGGCGCTGTCTGAGCGGACCGGCCGCAC
ATCCGCCTATTATATCCGCGAGGCGATCGAGAAGCATATCGAGGATATGGAAGACCTCTATCTTGCCGAAGAGGCGACGC
GGCGCATTCAGCGCGGAGAATCGAAGATTATAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0D1IYN8