Detailed information of TA system TA153683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1069430..1069907
• Replicon: chromosome
• Accession: NZ_CP051165
• Organism: Staphylococcus aureus strain NGA84b

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: HF584_RS05180
• Protein ID: WP_000052076.1
• Coordinates: 1069719..1069907 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: HF584_RS05175
• Protein ID: WP_001059689.1
• Coordinates: 1069430..1069690 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF584_RS05140 (1064823)	1064823..1065539	-	717	WP_054189299.1	type I 3-dehydroquinate dehydratase	-
HF584_RS05145 (1065687)	1065687..1066109	+	423	WP_000974455.1	organic hydroperoxide resistance protein	-
HF584_RS05150 (1066508)	1066508..1067002	+	495	WP_054189298.1	GNAT family N-acetyltransferase	-
HF584_RS05155 (1067158)	1067158..1067775	+	618	WP_054189297.1	LysE/ArgO family amino acid transporter	-
HF584_RS05160 (1067848)	1067848..1068429	-	582	WP_054189296.1	histidine phosphatase family protein	-
HF584_RS05165 (1068653)	1068653..1068889	+	237	WP_000368687.1	hypothetical protein	-
HF584_RS05170 (1068886)	1068886..1069089	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
HF584_RS05175 (1069430)	1069430..1069690	+	261	WP_001059689.1	hypothetical protein	Antitoxin
HF584_RS05180 (1069719)	1069719..1069907	+	189	WP_000052076.1	hypothetical protein	Toxin
HF584_RS05185 (1070096)	1070096..1070665	+	570	WP_054189295.1	lipoprotein N-acylation protein LnsA	-
HF584_RS05190 (1070753)	1070753..1071037	+	285	WP_054189294.1	hypothetical protein	-
HF584_RS05195 (1071099)	1071099..1071317	+	219	WP_054189293.1	hypothetical protein	-
HF584_RS05200 (1071815)	1071815..1072015	-	201	WP_001059082.1	cold-shock protein	-
HF584_RS05205 (1072372)	1072372..1073058	-	687	WP_054189292.1	thermonuclease family protein	-
HF584_RS05210 (1073400)	1073400..1073957	-	558	WP_054189291.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-115)

Antitoxin

• SpoVT-AbrB domain (14-52)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T153683 WP_000052076.1 NZ_CP051165:1069719-1069907 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T153683 NZ_CP067027:611686-612045 [Agrobacterium fabrum]
ATGGTCCGCAACCAGATCCCCAAGCGCGGCGACGTTTATCTGGTTGATCTAAACCCTGTCGTAGGCAGCGAAATCAAGGA
CGAACATCGCTGTGTCGTCATCACGCCCAGAGAAATTAACGCGGTCGGACTCTGTCTCGTCGTCCCGGTGACCACCGGCG
GCATGTTTACGCGCAAGGCAGGGCTTGCCGTAAATATATCCGGCCACAAGACAACGGGCGTCGCTTTGTGCAATCAGGTG
AGAAGCATGGATATCGTCGCCCGGGTTGCCCAGAAGAAAGCGAAATATATCGAAACCCTCGATGATGCGACGATCGATGA
AATCGCCGGGCGCGTCATCAGCATGATCGATCCAGCTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10009.20 Da
• Isoelectric Point: 4.4986

>AT153683 WP_001059689.1 NZ_CP051165:1069430-1069690 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYRFIG

Nucleotide

• Length: 261 bp

>AT153683 NZ_CP067027:611420-611686 [Agrobacterium fabrum]
ATGACCGTGACCACGAAAATAAGACGCCAGGGCGGCGCGGCGGTGATGACGATCCCGCCCGCTCTTTTGAAGATGCTGGG
GCTGGAAATCGGTGAGCAACTGACGCTCGAGGTCGATAATGGCGCTCTGGTGGCAAGCCCGGTTCGACTGGAAAAGAAAC
GCTTCACGCTGGCCGAATTACTGGATGGTGCAGAGGAAGTGGCAGCTCTAAACGCCAGGGAGCGGGCGTGGGACACAGCG
CCTCCTGTCGGCAAAGAAGCGTTGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18