Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 362019..362807 Replicon chromosome
Accession NZ_CP051165
Organism Staphylococcus aureus strain NGA84b

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag HF584_RS01805 Protein ID WP_000525004.1
Coordinates 362019..362480 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag HF584_RS01810 Protein ID WP_000333630.1
Coordinates 362493..362807 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF584_RS01780 (358965) 358965..360170 - 1206 WP_000264751.1 site-specific integrase -
HF584_RS01785 (360296) 360296..360910 + 615 WP_000191466.1 hypothetical protein -
HF584_RS01790 (360907) 360907..361053 - 147 WP_001795334.1 hypothetical protein -
HF584_RS01795 (361143) 361143..361538 - 396 WP_000449655.1 hypothetical protein -
HF584_RS01800 (361567) 361567..362001 - 435 WP_000755718.1 hypothetical protein -
HF584_RS01805 (362019) 362019..362480 - 462 WP_000525004.1 hypothetical protein Toxin
HF584_RS01810 (362493) 362493..362807 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
HF584_RS01815 (362959) 362959..363195 + 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
HF584_RS01820 (363209) 363209..363985 + 777 WP_001148544.1 Rha family transcriptional regulator -
HF584_RS01825 (364014) 364014..364157 + 144 WP_000939498.1 hypothetical protein -
HF584_RS01830 (364147) 364147..364356 - 210 WP_000642492.1 hypothetical protein -
HF584_RS01835 (364412) 364412..364657 + 246 WP_001025401.1 DUF2829 domain-containing protein -
HF584_RS01840 (364626) 364626..364991 - 366 WP_001128433.1 hypothetical protein -
HF584_RS01845 (365046) 365046..365261 + 216 WP_001097552.1 hypothetical protein -
HF584_RS01850 (365286) 365286..365549 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
HF584_RS01855 (365562) 365562..365723 + 162 WP_001285954.1 DUF1270 domain-containing protein -
HF584_RS01860 (365802) 365802..366125 + 324 WP_000175001.1 hypothetical protein -
HF584_RS01865 (366140) 366140..366502 + 363 WP_000985984.1 hypothetical protein -
HF584_RS01870 (366499) 366499..367665 + 1167 WP_000762547.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage dfrG lukS-PV / lukF-PV 354338..408893 54555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T153679 WP_000525004.1 NZ_CP051165:c362480-362019 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T153679 NZ_CP067025:c25924-25652 [Pseudomonas syringae pv. maculicola]
ATGACCTGGCGGATTGAATTTGATCCGGCAGCGGAAAAGGAACTGAAAGAACTTGGGGACGATGCAGCAAAGGACGTTCT
GAAATTTCTTGTTGGACGTATCACCAATCAAGGCGAACCACACAGTATTGGAAGCGCTCTGAAAGGCTCAGAGCTGGGCG
AGCTCTGGAAGTACCGAGTTGGAGACTATCGCATCGTTTCCAATATCCAGGACGTCACTTTAACCATTTTGGTTGTACGG
CTCAGCAGTCAGCAGAGAGGGTACAGACGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT153679 WP_000333630.1 NZ_CP051165:c362807-362493 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT153679 NZ_CP067025:c26132-25908 [Pseudomonas syringae pv. maculicola]
ATGTTAGCTATCCGTCTTGCCCCGGAAATAGAGGAGCGCCTAGAAGCATTGGCTGCTCGTACAGGACGCACCAAGACCTT
CTATGCCCGGGAAGCCATCCTCGAGCACATTGATGACCTAGAGGATCTGTACCTAGCTGAGCAGCGATTGGGAGAGGTGC
GTGAGAACCGTAGCGAAACGATTTCACTTCAAGACGTGATCAAGTCCTATGACCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References