Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 1500071..1500875 Replicon chromosome
Accession NZ_CP051162
Organism Geobacillus subterraneus strain CPW16

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag HF500_RS07580 Protein ID WP_168368306.1
Coordinates 1500071..1500490 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag HF500_RS07585 Protein ID WP_210436925.1
Coordinates 1500480..1500875 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF500_RS07555 1495206..1496900 + 1695 WP_168369010.1 M3 family oligoendopeptidase -
HF500_RS07560 1496980..1497495 + 516 WP_020959098.1 GNAT family N-acetyltransferase -
HF500_RS07565 1497628..1498296 + 669 WP_168368304.1 ABC transporter ATP-binding protein -
HF500_RS07570 1498353..1499378 + 1026 WP_020959100.1 ABC transporter permease -
HF500_RS07575 1499390..1500043 + 654 WP_168368305.1 TetR/AcrR family transcriptional regulator -
HF500_RS07580 1500071..1500490 - 420 WP_168368306.1 DUF86 domain-containing protein Toxin
HF500_RS07585 1500480..1500875 - 396 WP_210436925.1 nucleotidyltransferase domain-containing protein Antitoxin
HF500_RS07590 1500938..1501096 + 159 WP_156487387.1 hypothetical protein -
HF500_RS07595 1501074..1501301 + 228 Protein_1432 beta-glucuronidase -
HF500_RS07600 1501325..1501630 + 306 WP_174539025.1 hypothetical protein -
HF500_RS07605 1501652..1502145 + 494 Protein_1434 SDR family oxidoreductase -
HF500_RS07610 1502173..1502976 + 804 WP_168368308.1 ATP-dependent sacrificial sulfur transferase LarE -
HF500_RS07615 1503124..1503393 + 270 WP_063166490.1 hypothetical protein -
HF500_RS07620 1503398..1504147 + 750 WP_168369011.1 nickel pincer cofactor biosynthesis protein LarB -
HF500_RS07625 1504153..1505067 + 915 WP_020959114.1 LarC family nickel insertion protein -
HF500_RS07630 1505093..1505575 + 483 WP_020959115.1 DUF111 family protein -
HF500_RS07635 1505586..1505837 + 252 WP_063166488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(5-94)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16015.44 Da        Isoelectric Point: 7.3515

>T153672 WP_168368306.1 NZ_CP051162:c1500490-1500071 [Geobacillus subterraneus]
MKSDVIFNKISVIERCLKRIREEYNDNPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSVSKKMKAMIGFRNIAVHDYQQLNLGIVQAIVEQHLDDFKQFAEAILRYAKENN

Download         Length: 420 bp

>T153672 NZ_CP067022:c5642912-5642730 [Pseudomonas cannabina pv. alisalensis]
ATGAAGTGCAGCGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCGGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGATCATGGCAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14785.97 Da        Isoelectric Point: 4.5491

>AT153672 WP_210436925.1 NZ_CP051162:c1500875-1500480 [Geobacillus subterraneus]
METVIIQTLRPVLDPFVIYLFGSAARGALRPDSDVDIAFISEGEPYDPYELFLLAGQLADKLGRDVDLVDLRRASTVFQA
QVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLQQIAESGTIYEK

Download         Length: 396 bp

>AT153672 NZ_CP067022:c5642698-5642273 [Pseudomonas cannabina pv. alisalensis]
ATGTATCAATATCCATTGGATCAGCATCTGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTTACTGAAGCATTGAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGAGCAGC
GTCGCAAGATTCCCCAGGCCTCAGTCGTACCCGGTCATGAACTGTTAATGCGTTTGCCTGCGCTGACTGTTGCCAAAATC
ATGCTGTGGAATAGCTTGTTGGAAGAGGGCGTTAGTCGTGCTGAGCTAGCGCGTCGCCTGGGTTGCACGCGGCAAGTGGT
GTATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGTATTGAGCGGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References