Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4705937..4706453 Replicon chromosome
Accession NZ_CP051161
Organism Klebsiella pneumoniae strain 16BU137

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag HF572_RS23030 Protein ID WP_004192395.1
Coordinates 4705937..4706221 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag HF572_RS23035 Protein ID WP_004192397.1
Coordinates 4706211..4706453 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF572_RS23005 4701354..4701662 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
HF572_RS23010 4701747..4701920 + 174 WP_002886906.1 hypothetical protein -
HF572_RS23015 4701923..4702666 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HF572_RS23020 4703023..4705161 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HF572_RS23025 4705469..4705933 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HF572_RS23030 4705937..4706221 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF572_RS23035 4706211..4706453 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HF572_RS23040 4706531..4708441 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HF572_RS23045 4708464..4709618 - 1155 WP_004178372.1 lactonase family protein -
HF572_RS23050 4709685..4710425 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T153668 WP_004192395.1 NZ_CP051161:c4706221-4705937 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T153668 NZ_CP067021:c219100-218798 [Acinetobacter sp. CS-2]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT153668 WP_004192397.1 NZ_CP051161:c4706453-4706211 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT153668 NZ_CP067021:c218797-218516 [Acinetobacter sp. CS-2]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References