Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2559051..2560639 Replicon chromosome
Accession NZ_CP051161
Organism Klebsiella pneumoniae strain 16BU137

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag HF572_RS12515 Protein ID WP_004190166.1
Coordinates 2559051..2560373 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HF572_RS12520 Protein ID WP_002904790.1
Coordinates 2560373..2560639 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF572_RS12500 2554107..2556608 + 2502 WP_102010286.1 fimbrial biogenesis outer membrane usher protein -
HF572_RS12505 2556596..2557600 + 1005 WP_004190163.1 type 1 fimbrial protein -
HF572_RS12510 2557742..2559034 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HF572_RS12515 2559051..2560373 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
HF572_RS12520 2560373..2560639 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HF572_RS12525 2560904..2561230 - 327 WP_004143476.1 hydroxyisourate hydrolase -
HF572_RS12530 2561227..2561727 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HF572_RS12535 2561705..2563084 - 1380 WP_105910464.1 purine permease -
HF572_RS12540 2563430..2564584 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HF572_RS12545 2564565..2565488 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T153664 WP_004190166.1 NZ_CP051161:c2560373-2559051 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T153664 NZ_CP067014:1001751-1001846 [Staphylococcus pasteuri]
ATGTCTGAAATCTTTGTTCATATTATGACTACTGTTATCAGTGGTTGTATTGTTACGTTGTTTGCACATTGGCTACGGCA
TCGTAACGATAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT153664 WP_002904790.1 NZ_CP051161:c2560639-2560373 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT153664 NZ_CP067014:c1001912-1001878 [Staphylococcus pasteuri]
ACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References