Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4557731..4558350 Replicon chromosome
Accession NZ_CP051159
Organism Klebsiella pneumoniae strain 19PDR22

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HF574_RS22650 Protein ID WP_002892050.1
Coordinates 4557731..4557949 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HF574_RS22655 Protein ID WP_002892066.1
Coordinates 4557976..4558350 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF574_RS22615 4553778..4554041 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
HF574_RS22620 4554041..4554181 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HF574_RS22625 4554178..4554876 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
HF574_RS22630 4554977..4556428 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HF574_RS22635 4556403..4556873 - 471 WP_002892026.1 YlaC family protein -
HF574_RS22640 4556894..4557034 + 141 WP_004147370.1 hypothetical protein -
HF574_RS22645 4557006..4557572 - 567 WP_002892030.1 maltose O-acetyltransferase -
HF574_RS22650 4557731..4557949 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HF574_RS22655 4557976..4558350 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HF574_RS22660 4558836..4561982 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HF574_RS22665 4562005..4563198 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153632 WP_002892050.1 NZ_CP051159:c4557949-4557731 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T153632 NZ_CP066996:c1255225-1254734 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT153632 WP_002892066.1 NZ_CP051159:c4558350-4557976 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT153632 NZ_CP066996:c1255512-1255222 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References