Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 3844330..3844846 | Replicon | chromosome |
Accession | NZ_CP051159 | ||
Organism | Klebsiella pneumoniae strain 19PDR22 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J2XDK6 |
Locus tag | HF574_RS19230 | Protein ID | WP_002886902.1 |
Coordinates | 3844562..3844846 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | HF574_RS19225 | Protein ID | WP_002886901.1 |
Coordinates | 3844330..3844572 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF574_RS19210 | 3840359..3841099 | + | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
HF574_RS19215 | 3841165..3842319 | + | 1155 | WP_002886900.1 | lactonase family protein | - |
HF574_RS19220 | 3842342..3844252 | + | 1911 | WP_004152270.1 | BglG family transcription antiterminator | - |
HF574_RS19225 | 3844330..3844572 | + | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
HF574_RS19230 | 3844562..3844846 | + | 285 | WP_002886902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HF574_RS19235 | 3844850..3845314 | - | 465 | WP_002886903.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
HF574_RS19240 | 3845555..3847693 | - | 2139 | WP_002886904.1 | anaerobic ribonucleoside-triphosphate reductase | - |
HF574_RS19245 | 3848050..3848793 | - | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
HF574_RS19250 | 3848796..3848969 | - | 174 | WP_002886906.1 | hypothetical protein | - |
HF574_RS19255 | 3849054..3849362 | + | 309 | WP_002886907.1 | PTS sugar transporter subunit IIB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T153630 WP_002886902.1 NZ_CP051159:3844562-3844846 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T153630 NZ_CP066996:361454-361606 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT153630 WP_002886901.1 NZ_CP051159:3844330-3844572 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT153630 NZ_CP066996:361686-361820 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |