Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2484568..2485094 Replicon chromosome
Accession NZ_CP051159
Organism Klebsiella pneumoniae strain 19PDR22

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HF574_RS12540 Protein ID WP_000323025.1
Coordinates 2484807..2485094 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HF574_RS12535 Protein ID WP_000534858.1
Coordinates 2484568..2484807 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF574_RS12515 2480566..2481906 + 1341 WP_000589001.1 ISNCY family transposase -
HF574_RS12520 2482327..2482638 + 312 Protein_2459 transposase -
HF574_RS12530 2483889..2484305 + 417 Protein_2461 cation-efflux pump -
HF574_RS12535 2484568..2484807 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HF574_RS12540 2484807..2485094 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HF574_RS12545 2485166..2485324 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
HF574_RS12550 2485927..2486901 + 975 WP_004181899.1 hypothetical protein -
HF574_RS12555 2487099..2487476 - 378 WP_004181901.1 hypothetical protein -
HF574_RS12560 2488166..2489233 + 1068 WP_004181903.1 hypothetical protein -
HF574_RS12565 2489389..2489736 + 348 WP_004181904.1 hypothetical protein -
HF574_RS12570 2489815..2490048 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaSHV-12 - 2474022..2519944 45922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T153624 WP_000323025.1 NZ_CP051159:2484807-2485094 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T153624 NZ_CP066994:361240-361392 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT153624 WP_000534858.1 NZ_CP051159:2484568-2484807 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT153624 NZ_CP066994:361472-361606 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References