Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2477386..2478296 Replicon chromosome
Accession NZ_CP051159
Organism Klebsiella pneumoniae strain 19PDR22

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag HF574_RS12500 Protein ID WP_004026354.1
Coordinates 2477826..2478296 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag HF574_RS12495 Protein ID WP_004181895.1
Coordinates 2477386..2477829 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF574_RS12480 2474019..2475506 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
HF574_RS12485 2475592..2476014 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HF574_RS12490 2476014..2477285 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
HF574_RS12495 2477386..2477829 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
HF574_RS12500 2477826..2478296 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
HF574_RS12505 2478406..2478666 - 261 WP_004026352.1 hypothetical protein -
HF574_RS12510 2479237..2480418 - 1182 WP_078207741.1 IS481 family transposase -
HF574_RS12515 2480566..2481906 + 1341 WP_000589001.1 ISNCY family transposase -
HF574_RS12520 2482327..2482638 + 312 Protein_2459 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaSHV-12 - 2474022..2519944 45922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T153623 WP_004026354.1 NZ_CP051159:2477826-2478296 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T153623 NZ_CP066993:c4668191-4668039 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT153623 WP_004181895.1 NZ_CP051159:2477386-2477829 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT153623 NZ_CP066993:c4667959-4667825 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References