Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2250959..2251613 Replicon chromosome
Accession NZ_CP051159
Organism Klebsiella pneumoniae strain 19PDR22

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag HF574_RS11270 Protein ID WP_004144731.1
Coordinates 2250959..2251366 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HF574_RS11275 Protein ID WP_002916312.1
Coordinates 2251347..2251613 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF574_RS11250 2246959..2248692 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
HF574_RS11255 2248698..2249411 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HF574_RS11260 2249434..2250330 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HF574_RS11265 2250431..2250952 + 522 WP_002916308.1 flavodoxin FldB -
HF574_RS11270 2250959..2251366 - 408 WP_004144731.1 protein YgfX Toxin
HF574_RS11275 2251347..2251613 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HF574_RS11280 2251859..2252842 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HF574_RS11285 2252993..2253652 - 660 WP_002916317.1 hemolysin III family protein -
HF574_RS11290 2253816..2254127 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HF574_RS11295 2254177..2254905 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HF574_RS11300 2255024..2256457 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T153621 WP_004144731.1 NZ_CP051159:c2251366-2250959 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T153621 NZ_CP066993:3776389-3776880 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT153621 WP_002916312.1 NZ_CP051159:c2251613-2251347 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153621 NZ_CP066993:3776102-3776392 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References