Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4371819..4372654 Replicon chromosome
Accession NZ_CP051158
Organism Escherichia coli strain 17MR471

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6H2GFM1
Locus tag HF575_RS20780 Protein ID WP_065304416.1
Coordinates 4371819..4372196 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6H2GGB7
Locus tag HF575_RS20785 Protein ID WP_001285390.1
Coordinates 4372286..4372654 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF575_RS20740 4367089..4367580 - 492 WP_001300785.1 DUF1097 domain-containing protein -
HF575_RS20745 4367682..4368236 - 555 WP_001001921.1 molecular chaperone YcdY -
HF575_RS20750 4368260..4368997 - 738 WP_000283667.1 zinc-binding phosphatase -
HF575_RS20755 4369052..4369990 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
HF575_RS20765 4370461..4371303 - 843 WP_065304417.1 DUF4942 domain-containing protein -
HF575_RS20770 4371400..4371597 - 198 WP_086598277.1 DUF957 domain-containing protein -
HF575_RS20775 4371625..4371822 - 198 Protein_4041 hypothetical protein -
HF575_RS20780 4371819..4372196 - 378 WP_065304416.1 type IV toxin-antitoxin system toxin CbtA Toxin
HF575_RS20785 4372286..4372654 - 369 WP_001285390.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HF575_RS20790 4372704..4373348 - 645 WP_065304415.1 antitoxin of toxin-antitoxin stability system -
HF575_RS20795 4373363..4373584 - 222 WP_000692312.1 DUF987 domain-containing protein -
HF575_RS20800 4373653..4374129 - 477 WP_001186747.1 RadC family protein -
HF575_RS20805 4374144..4374629 - 486 WP_000214317.1 antirestriction protein -
HF575_RS20810 4374720..4375541 - 822 WP_106668205.1 DUF945 domain-containing protein -
HF575_RS20815 4375762..4376172 - 411 WP_000846713.1 hypothetical protein -
HF575_RS20820 4376188..4376865 - 678 WP_059239983.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 4363645..4393657 30012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14060.06 Da        Isoelectric Point: 7.8522

>T153611 WP_065304416.1 NZ_CP051158:c4372196-4371819 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ

Download         Length: 378 bp

>T153611 NZ_CP066988:c4639834-4639700 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.52 Da        Isoelectric Point: 5.9618

>AT153611 WP_001285390.1 NZ_CP051158:c4372654-4372286 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT153611 NZ_CP066988:c4640063-4639911 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GFM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GGB7

References