Detailed information of TA system TA153592

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 864643..865346
• Replicon: chromosome
• Accession: NZ_CP051158
• Organism: Escherichia coli strain 17MR471

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HF575_RS04080
• Protein ID: WP_040196446.1
• Coordinates: 864643..864984 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HF575_RS04085
• Protein ID: WP_044864456.1
• Coordinates: 865005..865346 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF575_RS04065	860775..861755	+	981	WP_001295601.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HF575_RS04070	861763..862413	-	651	WP_001037966.1	HNH endonuclease	-
HF575_RS04075	863377..864384	-	1008	WP_044864458.1	restriction endonuclease	-
HF575_RS04080	864643..864984	-	342	WP_040196446.1	TA system toxin CbtA family protein	Toxin
HF575_RS04085	865005..865346	-	342	WP_044864456.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HF575_RS04090	865357..865899	-	543	WP_044864455.1	DNA repair protein RadC	-
HF575_RS04095	865912..866352	-	441	WP_023329298.1	antirestriction protein	-
HF575_RS04100	866383..867204	-	822	WP_023329299.1	DUF945 domain-containing protein	-
HF575_RS04105	867324..867797	-	474	WP_044864453.1	hypothetical protein	-
HF575_RS04110	867869..868321	-	453	WP_160387433.1	hypothetical protein	-
HF575_RS04115	868357..869073	-	717	WP_044864451.1	WYL domain-containing protein	-
HF575_RS04120	869317..870192	-	876	WP_044864450.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	854099..890624	36525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12791.74 Da
• Isoelectric Point: 7.1648

>T153592 WP_040196446.1 NZ_CP051158:c864984-864643 [Escherichia coli]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Nucleotide

• Length: 342 bp

>T153592 NZ_CP066982:353466-353600 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12843.36 Da
• Isoelectric Point: 5.4792

>AT153592 WP_044864456.1 NZ_CP051158:c865346-865005 [Escherichia coli]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLIDRASITGDFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Nucleotide

• Length: 342 bp

>AT153592 NZ_CP066982:353234-353386 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA