Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1448873..1449495 Replicon chromosome
Accession NZ_CP051153
Organism Treponema vincentii strain OMZ 862

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4N73_RS06930 Protein ID WP_253806663.1
Coordinates 1449187..1449495 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S3MGF4
Locus tag E4N73_RS06925 Protein ID WP_006187504.1
Coordinates 1448873..1449190 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N73_RS06905 (E4N73_06940) 1444517..1445242 - 726 WP_006187508.1 glycogen-binding domain-containing protein -
E4N73_RS06910 (E4N73_06945) 1445370..1446446 - 1077 WP_253806660.1 tRNA-dihydrouridine synthase family protein -
E4N73_RS06915 (E4N73_06950) 1446513..1448165 - 1653 WP_253806661.1 nucleoside kinase -
E4N73_RS06925 (E4N73_06960) 1448873..1449190 - 318 WP_006187504.1 putative addiction module antidote protein Antitoxin
E4N73_RS06930 (E4N73_06965) 1449187..1449495 - 309 WP_253806663.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N73_RS06935 (E4N73_06970) 1449567..1451108 - 1542 WP_253806665.1 MiaB/RimO family radical SAM methylthiotransferase -
E4N73_RS06940 (E4N73_06975) 1451101..1452219 - 1119 WP_253806666.1 helix-turn-helix domain-containing protein -
E4N73_RS06945 (E4N73_06980) 1452301..1452987 - 687 WP_006187500.1 outer membrane lipoprotein carrier protein LolA -
E4N73_RS06950 (E4N73_06985) 1452988..1453215 + 228 WP_253806667.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11934.99 Da        Isoelectric Point: 10.4439

>T153586 WP_253806663.1 NZ_CP051153:c1449495-1449187 [Treponema vincentii]
MKVLKKTEVFNTWLSKLKDEKGKAKITDRIMRLKRGNKGDYRTIDKDIYELRIHFGSGYRIYCTDRNNEIILLLIAGDKS
TQSKDIKKAQQMIKLLEQGEAK

Download         Length: 309 bp

>T153586 NZ_CP066980:c4716196-4716062 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11720.38 Da        Isoelectric Point: 5.1473

>AT153586 WP_006187504.1 NZ_CP051153:c1449190-1448873 [Treponema vincentii]
MKITDFDPADYLTTKEAMIEYLNEALKTSIEDNTPEHFMEALGDVTRAQGITNAAKSTDLNREHLYRSLSKKGNPTFSTI
IKLIKFLGLEINITEAQSVKTAIAL

Download         Length: 318 bp

>AT153586 NZ_CP066980:c4716428-4716276 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S3MGF4

References