153583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 81995..82560 Replicon chromosome
Accession NZ_CP051153
Organism Treponema vincentii strain OMZ 862

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E4N73_RS00430 Protein ID WP_253807514.1
Coordinates 81995..82333 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID C8PTV1
Locus tag E4N73_RS00435 Protein ID WP_006190331.1
Coordinates 82327..82560 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N73_RS00415 (E4N73_00410) 77252..78259 - 1008 Protein_80 integron integrase -
E4N73_RS00420 (E4N73_00415) 78683..80296 - 1614 WP_253807512.1 Na+/H+ antiporter NhaC family protein -
E4N73_RS00425 (E4N73_00420) 80465..81631 + 1167 WP_253807513.1 DNA polymerase IV -
E4N73_RS00430 (E4N73_00425) 81995..82333 - 339 WP_253807514.1 endoribonuclease MazF Toxin
E4N73_RS00435 (E4N73_00430) 82327..82560 - 234 WP_006190331.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E4N73_RS00440 (E4N73_00435) 82784..83200 - 417 WP_016518919.1 EamA family transporter -
E4N73_RS00445 (E4N73_00440) 83381..84067 + 687 WP_253807515.1 hypothetical protein -
E4N73_RS00450 (E4N73_00445) 84262..84816 + 555 WP_253807516.1 hypothetical protein -
E4N73_RS00455 (E4N73_00450) 84925..85164 + 240 WP_253807517.1 hypothetical protein -
E4N73_RS00460 (E4N73_00455) 85284..85697 + 414 WP_253807518.1 hypothetical protein -
E4N73_RS00465 (E4N73_00460) 85715..86029 + 315 WP_253807519.1 hypothetical protein -
E4N73_RS00470 (E4N73_00465) 86066..86359 + 294 WP_253807520.1 hypothetical protein -
E4N73_RS00475 (E4N73_00470) 86381..86938 + 558 WP_253807521.1 DUF3486 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(12-110)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12741.75 Da        Isoelectric Point: 6.4688

>T153583 WP_253807514.1 NZ_CP051153:c82333-81995 [Treponema vincentii]
MVMSGFIPEKEDLVWLEFNPQAGHEQQGHRPAICVSQKLYNKKTGLALFCPITSHVKGYPFEVILNAHSIKGCILSDQIK
NMDYVQRKCSFIEKTSDDEINSVVDNIKLMIE

Download         Length: 339 bp

>T153583 NZ_CP066979:131229-131363 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8767.18 Da        Isoelectric Point: 8.6592

>AT153583 WP_006190331.1 NZ_CP051153:c82560-82327 [Treponema vincentii]
MQAVVQKWGNSLGLRIPSLWAKDNNIKNGSKIEIIAEKGKMIILPQKKSLEDFMNLVTDKNLHSEINTFEAVGKEEW

Download         Length: 234 bp

>AT153583 NZ_CP066979:130997-131149 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB C8PTV1

References