153582

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 860409..860933 Replicon chromosome
Accession NZ_CP051149
Organism Staphylococcus pseudintermedius strain 6109

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag HF583_RS03805 Protein ID WP_014613379.1
Coordinates 860580..860933 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag HF583_RS03800 Protein ID WP_014613378.1
Coordinates 860409..860579 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF583_RS03775 (HF583_03750) 856298..856771 + 474 WP_037542551.1 PH domain-containing protein -
HF583_RS03780 (HF583_03755) 856764..858293 + 1530 WP_037542554.1 PH domain-containing protein -
HF583_RS03785 (HF583_03760) 858277..858795 + 519 WP_014613375.1 PH domain-containing protein -
HF583_RS03790 (HF583_03765) 858792..859142 + 351 WP_037542556.1 holo-ACP synthase -
HF583_RS03795 (HF583_03770) 859176..860324 + 1149 WP_014613377.1 alanine racemase -
HF583_RS03800 (HF583_03775) 860409..860579 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HF583_RS03805 (HF583_03780) 860580..860933 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HF583_RS03810 (HF583_03785) 860991..861995 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
HF583_RS03815 (HF583_03790) 862074..862400 + 327 WP_014613381.1 anti-sigma factor antagonist -
HF583_RS03820 (HF583_03795) 862400..862879 + 480 WP_031253870.1 anti-sigma B factor RsbW -
HF583_RS03825 (HF583_03800) 862854..863624 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T153582 WP_014613379.1 NZ_CP051149:860580-860933 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T153582 NZ_CP066979:130997-131149 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT153582 WP_014613378.1 NZ_CP051149:860409-860579 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT153582 NZ_CP066979:131229-131363 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References