153581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 844159..844680 Replicon chromosome
Accession NZ_CP051149
Organism Staphylococcus pseudintermedius strain 6109

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag HF583_RS03725 Protein ID WP_014613364.1
Coordinates 844459..844680 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag HF583_RS03720 Protein ID WP_014613363.1
Coordinates 844159..844446 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF583_RS03695 (HF583_03670) 839420..840223 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
HF583_RS03700 (HF583_03675) 840213..840851 + 639 WP_014613359.1 thiamine phosphate synthase -
HF583_RS03705 (HF583_03680) 840940..841806 + 867 WP_014613360.1 membrane protein insertase YidC -
HF583_RS03710 (HF583_03685) 841860..842516 - 657 WP_014613361.1 HD domain-containing protein -
HF583_RS03715 (HF583_03690) 842537..844027 - 1491 WP_014613362.1 cardiolipin synthase -
HF583_RS03720 (HF583_03695) 844159..844446 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
HF583_RS03725 (HF583_03700) 844459..844680 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
HF583_RS03730 (HF583_03705) 844684..844890 + 207 WP_014613365.1 cation transporter -
HF583_RS03735 (HF583_03710) 844991..847171 + 2181 WP_037542539.1 heavy metal translocating P-type ATPase -
HF583_RS03740 (HF583_03715) 847257..847403 + 147 WP_014613367.1 Lmo0850 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T153581 WP_014613364.1 NZ_CP051149:844459-844680 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T153581 NZ_CP066978:3717407-3717898 [Xanthomonas campestris pv. incanae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGCCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT153581 WP_014613363.1 NZ_CP051149:844159-844446 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT153581 NZ_CP066978:3717120-3717410 [Xanthomonas campestris pv. incanae]
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCGCGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References