Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 844159..844680 | Replicon | chromosome |
Accession | NZ_CP051149 | ||
Organism | Staphylococcus pseudintermedius strain 6109 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | A0A3D8YLE8 |
Locus tag | HF583_RS03725 | Protein ID | WP_014613364.1 |
Coordinates | 844459..844680 (+) | Length | 74 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | A0A166R1D0 |
Locus tag | HF583_RS03720 | Protein ID | WP_014613363.1 |
Coordinates | 844159..844446 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF583_RS03695 (HF583_03670) | 839420..840223 | + | 804 | WP_014613358.1 | hydroxyethylthiazole kinase | - |
HF583_RS03700 (HF583_03675) | 840213..840851 | + | 639 | WP_014613359.1 | thiamine phosphate synthase | - |
HF583_RS03705 (HF583_03680) | 840940..841806 | + | 867 | WP_014613360.1 | membrane protein insertase YidC | - |
HF583_RS03710 (HF583_03685) | 841860..842516 | - | 657 | WP_014613361.1 | HD domain-containing protein | - |
HF583_RS03715 (HF583_03690) | 842537..844027 | - | 1491 | WP_014613362.1 | cardiolipin synthase | - |
HF583_RS03720 (HF583_03695) | 844159..844446 | + | 288 | WP_014613363.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
HF583_RS03725 (HF583_03700) | 844459..844680 | + | 222 | WP_014613364.1 | heavy metal-associated domain-containing protein | Toxin |
HF583_RS03730 (HF583_03705) | 844684..844890 | + | 207 | WP_014613365.1 | cation transporter | - |
HF583_RS03735 (HF583_03710) | 844991..847171 | + | 2181 | WP_037542539.1 | heavy metal translocating P-type ATPase | - |
HF583_RS03740 (HF583_03715) | 847257..847403 | + | 147 | WP_014613367.1 | Lmo0850 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 74 a.a. Molecular weight: 8065.10 Da Isoelectric Point: 4.3480
>T153581 WP_014613364.1 NZ_CP051149:844459-844680 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV
Download Length: 222 bp
>T153581 NZ_CP066978:3717407-3717898 [Xanthomonas campestris pv. incanae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGCCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGCCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10997.59 Da Isoelectric Point: 7.0504
>AT153581 WP_014613363.1 NZ_CP051149:844159-844446 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD
Download Length: 288 bp
>AT153581 NZ_CP066978:3717120-3717410 [Xanthomonas campestris pv. incanae]
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCGCGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCGCGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3D8YLE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A166R1D0 |