Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2442016..2442653 Replicon chromosome
Accession NZ_CP051148
Organism Treponema vincentii strain OMZ 861

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N72_RS11160 Protein ID WP_253812514.1
Coordinates 2442016..2442420 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N72_RS11165 Protein ID WP_253812516.1
Coordinates 2442420..2442653 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N72_RS11130 (E4N72_11205) 2437651..2438220 + 570 WP_253812502.1 AAA family ATPase -
E4N72_RS11135 (E4N72_11215) 2438358..2439905 - 1548 WP_253812504.1 RNA-directed DNA polymerase -
E4N72_RS11140 (E4N72_11220) 2440139..2440600 - 462 WP_253812506.1 hypothetical protein -
E4N72_RS11145 (E4N72_11225) 2440721..2441350 - 630 WP_253812508.1 protein kinase -
E4N72_RS11150 (E4N72_11230) 2441372..2441734 - 363 WP_253812510.1 DNA methylase -
E4N72_RS11155 (E4N72_11235) 2441664..2441993 - 330 WP_253812512.1 hypothetical protein -
E4N72_RS11160 (E4N72_11240) 2442016..2442420 - 405 WP_253812514.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N72_RS11165 (E4N72_11245) 2442420..2442653 - 234 WP_253812516.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N72_RS11170 (E4N72_11250) 2442715..2444046 - 1332 WP_253812518.1 ATP-binding protein -
E4N72_RS11175 (E4N72_11255) 2444043..2445854 - 1812 WP_253812520.1 TerB N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15533.94 Da        Isoelectric Point: 4.9225

>T153578 WP_253812514.1 NZ_CP051148:c2442420-2442016 [Treponema vincentii]
MYLLDTNICIFLIKNKFPVLTKKIFSANSDDLFLSAISIAEMEYGASKSQQREKNRQALLNFCADFNTILDFTTEDTEAY
GMIRAYLEKKGKIIGPYDIQIAAQAMTRNLIVITNNYDEFVRIPWIKLEDWTKE

Download         Length: 405 bp

>T153578 NZ_CP066975:4940865-4941020 [Xanthomonas campestris pv. campestris]
GTGACCCTGCTCGATACCAATGTCATCTTCGGGCCCAATCTGCATGTCGTCGCCTGGATCGATGTGCAGGCCGTTGAAAC
ACTGTTCCTGTCGGTCGTGACGGTGGCCGAATTGCGATCTGGAGACATTCAGGATTTCAGACCCCTGATGAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8931.15 Da        Isoelectric Point: 5.6479

>AT153578 WP_253812516.1 NZ_CP051148:c2442653-2442420 [Treponema vincentii]
MDCAKVFMSGNSQAVRIPKEFHIDQSELFIKKIGTTIILYPQNHPWENLRKSLSEFSDDFMSDGRNQPALPERESLF

Download         Length: 234 bp

>AT153578 NZ_CP066975:4940614-4940868 [Xanthomonas campestris pv. campestris]
ATGCCTTCTTTCACCGTCCGCAACATCCCGGAGGATGTGCATCGCGCCATCTGGGCACGTGCTGCCCAACACGGGCGCAG
CACCGAGGCGGAGATCCGCGCGATCCTTGAATCAGCAGCCAGGCCAGCCGACCAGGTCAAACTTGGCGCGTTGCTGGTGG
ACATCGGCCGCGACGCTGGCCTGACAGCAAAAGAGGCCGACGCCTTCGCCAAGTTACGCGACAAGGCCGCGATCAAGCCG
ATCGGTTTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References