Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 81864..82429 Replicon chromosome
Accession NZ_CP051148
Organism Treponema vincentii strain OMZ 861

Toxin (Protein)


Gene name mazF Uniprot ID C8PTV0
Locus tag E4N72_RS00420 Protein ID WP_006190329.1
Coordinates 81864..82202 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E4N72_RS00425 Protein ID WP_253812801.1
Coordinates 82196..82429 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N72_RS00405 (E4N72_00405) 77081..78076 - 996 WP_253812796.1 integron integrase -
E4N72_RS00410 (E4N72_00410) 78513..80126 - 1614 WP_253812798.1 Na+/H+ antiporter NhaC family protein -
E4N72_RS00415 (E4N72_00415) 80336..81502 + 1167 WP_253812800.1 DNA polymerase IV -
E4N72_RS00420 (E4N72_00425) 81864..82202 - 339 WP_006190329.1 endoribonuclease MazF Toxin
E4N72_RS00425 (E4N72_00430) 82196..82429 - 234 WP_253812801.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E4N72_RS00430 (E4N72_00435) 82544..83017 - 474 WP_253812803.1 GNAT family N-acetyltransferase -
E4N72_RS00435 (E4N72_00440) 83334..83957 + 624 WP_253812805.1 TetR/AcrR family transcriptional regulator -
E4N72_RS00440 (E4N72_00445) 83981..84436 + 456 WP_006190348.1 hypothetical protein -
E4N72_RS00445 (E4N72_00450) 84660..85007 + 348 WP_253812807.1 flavodoxin -
E4N72_RS00450 (E4N72_00455) 85355..85837 + 483 WP_253807567.1 GNAT family N-acetyltransferase -
E4N72_RS00455 (E4N72_00460) 86259..86861 + 603 WP_253812809.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12639.66 Da        Isoelectric Point: 6.8427

>T153576 WP_006190329.1 NZ_CP051148:c82202-81864 [Treponema vincentii]
MVMSGFIPEKGDLVWLEFNPQAGHEQQGHRPAICVSQKLYNKKTGLALFCPITSHVKGYPFEVILNAHSIKGCILSDQIK
NMDYVQRKCSFIEKASDDEINSVVDNIKLMIE

Download         Length: 339 bp

>T153576 NZ_CP066975:c4607719-4607585 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8766.24 Da        Isoelectric Point: 10.1462

>AT153576 WP_253812801.1 NZ_CP051148:c82429-82196 [Treponema vincentii]
MQAVVQKWGNSLGLRIPSLWAKDNNIKNGSKIEIIAEKGKMIILPQKKSLEDFMNLVTDKNLHSEINTFEAVGKEKW

Download         Length: 234 bp

>AT153576 NZ_CP066975:c4607948-4607796 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C8PTV0

Antitoxin

Source ID Structure

References