Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1803204..1803783 Replicon chromosome
Accession NZ_CP051147
Organism Treponema sp. OMZ 857

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4N66_RS08170 Protein ID WP_044012884.1
Coordinates 1803592..1803783 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4N66_RS08165 Protein ID WP_044012882.1
Coordinates 1803204..1803587 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N66_RS08145 (E4N66_08180) 1798789..1799301 - 513 WP_253727611.1 TIGR03546 family protein -
E4N66_RS08150 (E4N66_08185) 1799712..1800398 + 687 WP_253727612.1 outer membrane lipoprotein carrier protein LolA -
E4N66_RS08155 (E4N66_08190) 1800436..1801554 + 1119 WP_253727613.1 helix-turn-helix domain-containing protein -
E4N66_RS08160 (E4N66_08195) 1801547..1803064 + 1518 WP_253727614.1 MiaB/RimO family radical SAM methylthiotransferase -
E4N66_RS08165 (E4N66_08200) 1803204..1803587 - 384 WP_044012882.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N66_RS08170 (E4N66_08205) 1803592..1803783 - 192 WP_044012884.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N66_RS08180 (E4N66_08215) 1804789..1806441 + 1653 WP_253727615.1 nucleoside kinase -
E4N66_RS08185 (E4N66_08220) 1806452..1806922 - 471 WP_253727616.1 Cys-tRNA(Pro) deacylase -
E4N66_RS08190 (E4N66_08225) 1806967..1808439 - 1473 WP_253727617.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-102)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7385.64 Da        Isoelectric Point: 10.2485

>T153575 WP_044012884.1 NZ_CP051147:c1803783-1803592 [Treponema sp. OMZ 857]
MNFKEMEKMIKQDGWIKRDIVGSHHHYEHPIKKGKVTIPFHGNKELSKFVVNSILKQAGLKEE

Download         Length: 192 bp

>T153575 NZ_CP066975:c1332323-1331832 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14303.44 Da        Isoelectric Point: 4.3514

>AT153575 WP_044012882.1 NZ_CP051147:c1803587-1803204 [Treponema sp. OMZ 857]
MYIYPAMFYKDENGYSVVFYDIELATMGDTLEEALIMAEEALTGRISLLLKDGETLPNPTAIEDIEKPKDAEFITLVKTD
RKYLAQEKSVRKNLTIPAWLAEAAENAGLNFSQELQCALKTRLHIGI

Download         Length: 384 bp

>AT153575 NZ_CP066975:c1332610-1332320 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References