Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 758857..759422 Replicon chromosome
Accession NZ_CP051147
Organism Treponema sp. OMZ 857

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E4N66_RS03535 Protein ID WP_253728980.1
Coordinates 758857..759195 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E4N66_RS03540 Protein ID WP_253728981.1
Coordinates 759189..759422 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N66_RS03500 (E4N66_03480) 754250..754705 - 456 WP_253728974.1 hypothetical protein -
E4N66_RS03505 (E4N66_03485) 754803..755633 - 831 WP_253728975.1 hypothetical protein -
E4N66_RS03510 (E4N66_03490) 755707..756582 - 876 WP_253728976.1 hypothetical protein -
E4N66_RS03515 (E4N66_03495) 756668..757057 - 390 WP_253728977.1 toxin-antitoxin system HicB family antitoxin -
E4N66_RS03520 (E4N66_03500) 757059..757427 - 369 WP_253728978.1 type II toxin-antitoxin system HicA family toxin -
E4N66_RS03525 (E4N66_03505) 757557..758390 - 834 WP_253728979.1 IS3 family transposase -
E4N66_RS03530 (E4N66_03510) 758453..758725 - 273 WP_044013562.1 transposase -
E4N66_RS03535 (E4N66_03515) 758857..759195 - 339 WP_253728980.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E4N66_RS03540 (E4N66_03520) 759189..759422 - 234 WP_253728981.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E4N66_RS03545 (E4N66_03525) 759816..760703 - 888 WP_253728982.1 hypothetical protein -
E4N66_RS03550 (E4N66_03530) 761087..762091 + 1005 WP_253728983.1 IS110 family transposase -
E4N66_RS03555 (E4N66_03535) 762288..762551 - 264 WP_253728984.1 hypothetical protein -
E4N66_RS03560 762551..763186 - 636 WP_253728985.1 ISAs1 family transposase -
E4N66_RS03565 763155..763709 - 555 WP_253728986.1 ISAs1 family transposase -
E4N66_RS03570 (E4N66_03545) 763687..764175 - 489 WP_253728987.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12992.95 Da        Isoelectric Point: 7.1879

>T153574 WP_253728980.1 NZ_CP051147:c759195-758857 [Treponema sp. OMZ 857]
MVNSNYVPDRGDLVWLDFNPQARHEQKGRRPAICIFQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKITEEEINAVVDNIKLLIE

Download         Length: 339 bp

>T153574 NZ_CP066972:4940898-4941053 [Xanthomonas campestris pv. campestris]
GTGACCCTGCTCGATACCAATGTCATCTTCGGGCCCAATCTGCATGTCGTCGCCTGGATCGATGTGCAGGCCGTTGAAAC
ACTGTTCCTGTCGGTCGTGACGGTGGCCGAATTGCGATCTGGAGACATTCAGGATTTCAGACCCCTGATGAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8625.96 Da        Isoelectric Point: 7.0094

>AT153574 WP_253728981.1 NZ_CP051147:c759422-759189 [Treponema sp. OMZ 857]
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIVEKGKIVILPQKKTLDDMLAMVTSENVHSEISTGYPVGNEEW

Download         Length: 234 bp

>AT153574 NZ_CP066972:4940647-4940901 [Xanthomonas campestris pv. campestris]
ATGCCTTCTTTCACCGTCCGCAACATCCCGGAGGATGTGCATCGCGCCATCTGGGCACGTGCTGCCCAACACGGGCGCAG
CACCGAGGCGGAGATCCGCGCGATCCTTGAATCAGCAGCCAGGCCAGCCGACCAGGTCAAACTTGGCGCGTTGCTGGTGG
ACATCGGCCGCGACGCTGGCCTGACAGCAAAAGAGGCCGACGCCTTCGCCAAGTTACGCGACAAGGCCGCGATCAAGCCG
ATCGGTTTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References