Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 436442..436929 Replicon chromosome
Accession NZ_CP051147
Organism Treponema sp. OMZ 857

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E4N66_RS01955 Protein ID WP_253673076.1
Coordinates 436442..436708 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N66_RS01960 Protein ID WP_253728761.1
Coordinates 436708..436929 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N66_RS01935 (E4N66_01950) 432021..433583 - 1563 WP_044014981.1 citrate lyase subunit alpha -
E4N66_RS01940 (E4N66_01955) 433586..434494 - 909 WP_253728759.1 aldolase/citrate lyase family protein -
E4N66_RS01945 (E4N66_01960) 434522..434809 - 288 WP_253673082.1 citrate lyase acyl carrier protein -
E4N66_RS01950 (E4N66_01965) 435092..436135 + 1044 WP_253728760.1 [citrate (pro-3S)-lyase] ligase -
E4N66_RS01955 (E4N66_01970) 436442..436708 - 267 WP_253673076.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N66_RS01960 (E4N66_01975) 436708..436929 - 222 WP_253728761.1 DUF6290 family protein Antitoxin
E4N66_RS01965 (E4N66_01980) 437062..437481 - 420 WP_253728762.1 PIN domain-containing protein -
E4N66_RS01970 (E4N66_01985) 437474..437713 - 240 WP_253728763.1 DUF6364 family protein -
E4N66_RS01975 (E4N66_01990) 437991..439385 + 1395 WP_253729420.1 ribosome biogenesis GTPase Der -
E4N66_RS01980 (E4N66_01995) 439361..439741 + 381 WP_253728764.1 MerR family transcriptional regulator -
E4N66_RS01985 (E4N66_02000) 439841..440443 + 603 WP_253728765.1 hypothetical protein -
E4N66_RS01990 (E4N66_02005) 440464..441252 + 789 WP_044014995.1 RNA polymerase sigma factor WhiG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10373.87 Da        Isoelectric Point: 9.9931

>T153573 WP_253673076.1 NZ_CP051147:c436708-436442 [Treponema sp. OMZ 857]
MYRVETTARFDKEFKKLDKYTQRMIAAWIDKNLEGSENPRVHGKGLTANRSGQWRYRIGDYRLICAIQDNELVILALTIG
HRRAVYDQ

Download         Length: 267 bp

>T153573 NZ_CP066972:c4607981-4607829 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8147.25 Da        Isoelectric Point: 5.1069

>AT153573 WP_253728761.1 NZ_CP051147:c436929-436708 [Treponema sp. OMZ 857]
MAFSIRLTEAEKAIANSYAKLHSVSLGEAFKNALFEKIEDEYDITVAAEAYQEYVSAGKKSRPFSELKKELGL

Download         Length: 222 bp

>AT153573 NZ_CP066972:c4607752-4607618 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References