Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1643662..1644274 Replicon chromosome
Accession NZ_CP051138
Organism Streptococcus pyogenes strain 4063-05

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag HFV09_RS08280 Protein ID WP_002988077.1
Coordinates 1643939..1644274 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag HFV09_RS08275 Protein ID WP_002988079.1
Coordinates 1643662..1643949 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFV09_RS08250 1638851..1639834 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
HFV09_RS08255 1639838..1640767 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
HFV09_RS08260 1640815..1641330 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
HFV09_RS08265 1641365..1641793 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
HFV09_RS08270 1642239..1643012 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
HFV09_RS08275 1643662..1643949 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
HFV09_RS08280 1643939..1644274 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFV09_RS08285 1644413..1644589 + 177 Protein_1573 tyrosine-type recombinase/integrase -
HFV09_RS08290 1644720..1645112 - 393 WP_002982716.1 30S ribosomal protein S9 -
HFV09_RS08295 1645133..1645579 - 447 WP_002982710.1 50S ribosomal protein L13 -
HFV09_RS08300 1645797..1646003 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
HFV09_RS08305 1646000..1646698 - 699 WP_021299047.1 hypothetical protein -
HFV09_RS08310 1646834..1647694 - 861 WP_011529009.1 DegV family protein -
HFV09_RS08315 1647791..1648309 - 519 WP_011055010.1 NYN domain-containing protein -
HFV09_RS08320 1648313..1649059 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T153572 WP_002988077.1 NZ_CP051138:1643939-1644274 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T153572 NZ_CP066972:c4607752-4607618 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT153572 WP_002988079.1 NZ_CP051138:1643662-1643949 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT153572 NZ_CP066972:c4607981-4607829 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References