Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 12344..12870 Replicon plasmid pAMS-38c
Accession NZ_CP051135
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HDB52_RS24250 Protein ID WP_000323025.1
Coordinates 12344..12631 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HDB52_RS24255 Protein ID WP_000534858.1
Coordinates 12631..12870 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS24215 7914..8090 - 177 WP_001371930.1 hypothetical protein -
HDB52_RS24220 8601..9545 + 945 WP_000778029.1 DUF5417 domain-containing protein -
HDB52_RS24225 9644..10243 + 600 WP_001031420.1 hypothetical protein -
HDB52_RS24230 10303..10653 + 351 WP_000743059.1 hypothetical protein -
HDB52_RS24235 10700..10903 + 204 WP_001015183.1 hypothetical protein -
HDB52_RS24240 11185..11505 + 321 WP_000332796.1 hypothetical protein -
HDB52_RS24245 12114..12272 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
HDB52_RS24250 12344..12631 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HDB52_RS24255 12631..12870 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HDB52_RS24260 13133..14056 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
HDB52_RS24265 14256..14828 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HDB52_RS24270 15304..16542 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaVIM-4 / aac(6')-Il / dfrA1 / aadA1 / qacE / sul1 / blaTEM-1B / ant(2'')-Ia / aadA2 / qnrA1 / mcr-9 - 1..281030 281030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T153570 WP_000323025.1 NZ_CP051135:c12631-12344 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T153570 NZ_CP066970:c4676331-4676179 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT153570 WP_000534858.1 NZ_CP051135:c12870-12631 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT153570 NZ_CP066970:c4676102-4675968 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References