Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4502317..4503056 Replicon chromosome
Accession NZ_CP051132
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag HDB52_RS21550 Protein ID WP_003857133.1
Coordinates 4502317..4502802 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag HDB52_RS21555 Protein ID WP_003857131.1
Coordinates 4502790..4503056 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS21525 4497689..4498447 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
HDB52_RS21530 4498552..4499844 + 1293 WP_032648327.1 glycoside hydrolase -
HDB52_RS21535 4499844..4500458 + 615 WP_065420578.1 NUDIX hydrolase -
HDB52_RS21540 4500716..4501681 + 966 WP_032648329.1 hypothetical protein -
HDB52_RS21545 4501697..4502266 + 570 WP_032648331.1 hypothetical protein -
HDB52_RS21550 4502317..4502802 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
HDB52_RS21555 4502790..4503056 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
HDB52_RS21560 4503120..4504049 - 930 WP_032648334.1 LysR family transcriptional regulator -
HDB52_RS21565 4504179..4505561 + 1383 WP_032648336.1 MFS transporter -
HDB52_RS21570 4505583..4506578 - 996 WP_168728657.1 DUF2891 domain-containing protein -
HDB52_RS21575 4506588..4507574 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(58-151)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T153568 WP_003857133.1 NZ_CP051132:c4502802-4502317 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T153568 NZ_CP066970:c1270869-1270378 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT153568 WP_003857131.1 NZ_CP051132:c4503056-4502790 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT153568 NZ_CP066970:c1271156-1270866 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9


Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References