Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 3928199..3928996 Replicon chromosome
Accession NZ_CP051132
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name KacT Uniprot ID A0A222RDD1
Locus tag HDB52_RS18760 Protein ID WP_032647926.1
Coordinates 3928475..3928996 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag HDB52_RS18755 Protein ID WP_015570876.1
Coordinates 3928199..3928468 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS18720 3923739..3924098 + 360 WP_032647921.1 helix-turn-helix transcriptional regulator -
HDB52_RS18725 3924108..3924272 - 165 WP_017693668.1 helix-turn-helix transcriptional regulator -
HDB52_RS18730 3924425..3925666 + 1242 WP_032647923.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
HDB52_RS18735 3925699..3925926 - 228 WP_006809324.1 YccJ family protein -
HDB52_RS18740 3925945..3926541 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
HDB52_RS18745 3926933..3927103 + 171 WP_001273664.1 general stress protein -
HDB52_RS18750 3927220..3928125 + 906 WP_017693666.1 DMT family transporter -
HDB52_RS18755 3928199..3928468 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
HDB52_RS18760 3928475..3928996 + 522 WP_032647926.1 GNAT family N-acetyltransferase Toxin
HDB52_RS18765 3929055..3930377 - 1323 WP_032647928.1 pyrimidine utilization transport protein G -
HDB52_RS18770 3930399..3930890 - 492 WP_032647931.1 pyrimidine utilization flavin reductase protein F -
HDB52_RS18775 3930903..3931493 - 591 WP_032647932.1 malonic semialdehyde reductase -
HDB52_RS18780 3931503..3932303 - 801 WP_032647935.1 pyrimidine utilization protein D -
HDB52_RS18785 3932311..3932697 - 387 WP_015570870.1 pyrimidine utilization protein C -
HDB52_RS18790 3932709..3933398 - 690 WP_017384771.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19451.21 Da        Isoelectric Point: 7.4318

>T153567 WP_032647926.1 NZ_CP051132:3928475-3928996 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

>T153567 NZ_CP066969:c1376912-1376421 [Xanthomonas campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCTTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT153567 WP_015570876.1 NZ_CP051132:3928199-3928468 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT153567 NZ_CP066969:c1377199-1376909 [Xanthomonas campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACAATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222RDD1

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References