Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3329576..3330196 Replicon chromosome
Accession NZ_CP051132
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HDB52_RS16025 Protein ID WP_015571250.1
Coordinates 3329576..3329794 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HDB52_RS16030 Protein ID WP_006809850.1
Coordinates 3329822..3330196 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS15995 3325588..3325848 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HDB52_RS16000 3325851..3325991 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HDB52_RS16005 3325988..3326698 - 711 WP_032647453.1 GNAT family N-acetyltransferase -
HDB52_RS16010 3326800..3328260 + 1461 WP_032647455.1 PLP-dependent aminotransferase family protein -
HDB52_RS16015 3328232..3328699 - 468 WP_015571252.1 extracytoplasmic function sigma factor YlaC -
HDB52_RS16020 3328816..3329367 - 552 WP_032647457.1 maltose O-acetyltransferase -
HDB52_RS16025 3329576..3329794 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HDB52_RS16030 3329822..3330196 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HDB52_RS16035 3330707..3333853 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
HDB52_RS16040 3333876..3335069 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T153565 WP_015571250.1 NZ_CP051132:c3329794-3329576 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T153565 NZ_CP066969:431372-431524 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT153565 WP_006809850.1 NZ_CP051132:c3330196-3329822 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT153565 NZ_CP066969:431601-431735 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References