Detailed information of TA system TA153564

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3190554..3191269
• Replicon: chromosome
• Accession: NZ_CP051132
• Organism: Enterobacter hormaechei strain AMS-38

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8I0UM05
• Locus tag: HDB52_RS15385
• Protein ID: WP_023303149.1
• Coordinates: 3190901..3191269 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8I0UJV2
• Locus tag: HDB52_RS15380
• Protein ID: WP_023303148.1
• Coordinates: 3190554..3190880 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HDB52_RS15355	3185588..3186853	+	1266	WP_023303143.1	hypothetical protein	-
HDB52_RS15360	3187162..3187596	+	435	WP_023303144.1	hypothetical protein	-
HDB52_RS15365	3187655..3188494	+	840	WP_023303145.1	hypothetical protein	-
HDB52_RS15370	3189184..3190005	+	822	WP_023303146.1	DUF945 domain-containing protein	-
HDB52_RS15375	3190071..3190541	+	471	WP_023303147.1	DNA repair protein RadC	-
HDB52_RS15380	3190554..3190880	+	327	WP_023303148.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HDB52_RS15385	3190901..3191269	+	369	WP_023303149.1	TA system toxin CbtA family protein	Toxin
HDB52_RS15390	3191619..3192365	-	747	WP_032647364.1	class I SAM-dependent methyltransferase	-
HDB52_RS15395	3192376..3192633	-	258	WP_003863178.1	YjhX family toxin	-
HDB52_RS15400	3192893..3194830	-	1938	WP_032647366.1	bifunctional diguanylate cyclase/phosphodiesterase	-
HDB52_RS15405	3194848..3195342	-	495	WP_023295996.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13727.91 Da
• Isoelectric Point: 8.2822

>T153564 WP_023303149.1 NZ_CP051132:3190901-3191269 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Nucleotide

• Length: 369 bp

>T153564 NZ_CP066968:c1153346-1152855 [Xanthomonas campestris pv. incanae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGGTGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12215.04 Da
• Isoelectric Point: 7.0266

>AT153564 WP_023303148.1 NZ_CP051132:3190554-3190880 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 327 bp

>AT153564 NZ_CP066968:c1153633-1153343 [Xanthomonas campestris pv. incanae]
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA